Fine-tuning of cross-bridge kinetics in cardiac muscle of rat and mouse by myosin light chain isoforms.

Pflügers Archiv : European journal of physiology
Oleg AndruchovStefan Galler

Abstract

Cross-bridge kinetics underlying stretch-induced force transients was studied in cardiac muscle strips with different myosin heavy chain (MHC) and myosin light chain (MLC) isoforms. The force transients were induced by stepwise stretches of maximally Ca(2+)-activated skinned muscle strips. The MHC and MLC isoforms were analyzed by electrophoreses after the mechanical experiments. Muscle strips of euthyroid rats and mice exclusively containing alpha-MHC were used. In addition, muscle strips of hyper- and hypothyroid rats containing different combinations of MHC and MLC isoforms were used. The thyroid hormone is known to alter the expression of MHC but not of MLC isoforms. In muscle strips containing exclusively alpha-MHC, atrial MLC isoforms (all atria of rats and mice) were associated with about 30% faster kinetics than ventricular MLC isoforms (ventricles of hyperthyroid rats and some muscle strips of ventricles of euthyroid rats and mice). On the other hand, in muscle strips containing exclusively ventricular MLC isoforms, alpha-MHC (ventricles of hyperthyroid rats) was associated with about 2.6 times faster kinetics than beta-MHC (ventricles of hypothyroid rats). We conclude that the MLC isoforms fine-tune cross-bridge kinet...Continue Reading

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Citations

Dec 2, 2010·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Sally F GilliverHans Degens
Jan 24, 2009·Pflügers Archiv : European journal of physiology·Robert StehleCorrado Poggesi
Apr 14, 2009·Journal of Molecular Biology·Katarzyna KazmierczakDanuta Szczesna-Cordary
Sep 14, 2012·Journal of Cellular and Molecular Medicine·Sören WagnerOliver Friedrich
Mar 6, 2008·Journal of Muscle Research and Cell Motility·Joseph F Y HohGunther H Rossmanith
Nov 18, 2016·Journal of Neuromuscular Diseases·Spandan KalraChris Denning

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