Fine-tuning of hematopoietic stem cell homeostasis: novel role for ubiquitin ligase.

Genes & Development
Tomomasa Yokomizo, Elaine Dzierzak

Abstract

Homeostasis of hematopoietic stem cells (HSCs) is a tightly regulated process, controlled by intrinsic and extrinsic signals. Although a variety of molecules involved in HSC maintenance and self-renewal are known, it remains unclear how robust HSC homeostasis is achieved. In this issue of Genes & Development, Rathinam and colleagues (992-997) report a new player in HSC homeostasis, c-Cbl ubiquitin ligase. They show that this E3 ubiquitin ligase acts as a negative regulator of cytokine signaling.

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Citations

Apr 12, 2011·Nature Immunology·Chozhavendan RathinamRichard A Flavell
Apr 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chozhavendan Rathinam, Richard A Flavell
Aug 3, 2010·PloS One·Brandon Beagle, Gail V W Johnson
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Jun 30, 2015·Oncotarget·Chozha Rathinam
Jun 6, 2017·Frontiers in Molecular Neuroscience·Arun UpadhyayAmit Mishra

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