Fine tuning of TCR signaling by CD5

The Journal of Immunology : Official Journal of the American Association of Immunologists
H S AzzamP E Love

Abstract

Current data indicate that CD5 functions as an inhibitor of TCR signal transduction. Consistent with this role, thymocyte selection in TCR transgenic/CD5(-/-) mice is altered in a manner suggestive of enhanced TCR signaling. However, the impact of CD5 deletion on thymocyte selection varies depending on the transgenic TCR analyzed, ranging from a slight to a marked shift from positive toward negative selection. An explanation for the variable effect of CD5 on selection is suggested by the observation that CD5 surface expression is regulated by TCR signal intensity during development and CD5 surface levels on mature thymocytes and T cells parallel the avidity of the positively selecting TCR/MHC/ligand interaction. In this study, we generated mice that overexpress CD5 during thymocyte development (CD5-tg), and then examined the effect of CD5 overexpression or CD5 deletion (CD5(-/-)) on selection of thymocytes that express the same TCR transgenes. The results demonstrate that the effect on thymocyte selection of altering CD5 expression depends on the avidity of the selecting interaction and, consequently, the level of basal (endogenous) CD5 surface expression. Substitution of endogenous CD5 with a transgene encoding a truncated for...Continue Reading

References

Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A A DaviesM J Crumpton
Jan 1, 1990·The Journal of Clinical Investigation·J B ImbodenJ A Ledbetter
Jan 1, 1990·Annual Review of Immunology·H von Boehmer
Mar 30, 1989·Nature·M Reth
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H J HuangL A Herzenberg
Jul 1, 1994·European Journal of Immunology·A TarakhovskyK Rajewsky
Jun 1, 1995·The Journal of Experimental Medicine·M L Thomas
Jan 1, 1995·Annual Review of Immunology·S C JamesonM J Bevan
Jan 1, 1994·Annual Review of Immunology·E Robey, B J Fowlkes
May 1, 1994·The Journal of Experimental Medicine·P E LoveA Singer
Sep 1, 1996·Immunity·R L Wange, L E Samelson
Nov 1, 1996·The Journal of Experimental Medicine·C P LiuP Marrack
Sep 1, 1996·The Journal of Experimental Medicine·G PaniK A Siminovitch
Jul 21, 1998·The Journal of Biological Chemistry·C RamanR P Kimberly
Dec 22, 1998·The Journal of Experimental Medicine·H S AzzamP E Love
Jun 8, 1999·Annual Review of Immunology·E SebzdaP S Ohashi
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P E LoveE W Shores

❮ Previous
Next ❯

Citations

May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erin JanssenWeiguo Zhang
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guillaume DorothéeFathia Mami-Chouaib
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mary E KeirArlene H Sharpe
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shoji UeharaPaul E Love
May 17, 2006·International Immunology·Alina BoesteanuAndrew J Caton
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raymond J SteptoeLeonard C Harrison
Nov 26, 2009·Nature Reviews. Immunology·Kensuke Takada, Stephen C Jameson
May 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zuopeng WuChristopher C Goodnow
Dec 15, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ni FengMary A Yui
Dec 1, 2011·The Journal of Biological Chemistry·Ian B FisherNatarajan Muthusamy
Jan 10, 2012·Annual Review of Immunology·Steven Z JosefowiczAlexander Y Rudensky
Jan 18, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monica W BuckleyKodi S Ravichandran
Dec 24, 2015·Frontiers in Immunology·Ashley Viehmann Milam, Paul M Allen
Apr 19, 2016·Immunological Reviews·Nadia Kurd, Ellen A Robey
Oct 8, 2016·Annual Review of Cell and Developmental Biology·Nicholas R J GascoigneJoanna Brzostek
Dec 29, 2016·PloS One·Carlos A Mier-AguilarGloria Soldevila
Mar 17, 2017·Pathology Oncology Research : POR·Ping ChenGang Zhao
Nov 9, 2017·PLoS Biology·Jiyoung OhDong-Ming Su
May 2, 2018·Proceedings of the National Academy of Sciences of the United States of America·Allyson SpenceQizhi Tang
Jan 25, 2019·Journal of Leukocyte Biology·Erica Burgueño-BucioGloria Soldevila
May 1, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nabil ZeidanVibhuti P Dave
Jul 10, 2019·Proceedings of the National Academy of Sciences of the United States of America·Wendy M Zinzow-KramerByron B Au-Yeung
Jun 10, 2020·Proceedings of the National Academy of Sciences of the United States of America·Courtney A MatsonNevil J Singh
Aug 1, 2020·Frontiers in Immunology·Alexandra TsitsiklisEllen A Robey
Jul 15, 2003·Nature Immunology·Matilde CanellesB J Fowlkes
Feb 2, 2006·Immunological Reviews·Karen LakyB J Fowlkes
Aug 26, 2006·European Journal of Immunology·Angèle BénardAntonius G Rolink
Apr 17, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ursula B FischerElizabeth Ingulli
Feb 11, 2004·Nature Immunology·Patrick S CostelloRichard Treisman
Feb 11, 2004·Nature Immunology·Xiaolong Liu, Rémy Bosselut
Aug 19, 2007·The Journal of Experimental Medicine·Karen Laky, B J Fowlkes
Jan 22, 2005·Journal of Leukocyte Biology·Nathalie NiederbergerNicholas R J Gascoigne
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bruno MartinBruno Lucas
Aug 19, 2005·Molecular and Cellular Biology·Luca SimeoniBurkhart Schraven
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nabil BoscoRhodri Ceredig
Dec 23, 2009·FEBS Letters·Rute R da FonsecaRasmus Nielsen
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claire E PerchonockVirginia Smith Shapiro
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Uwe KoelschLuca Simeoni
Nov 16, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robert BerlandHenry H Wortis
May 2, 2008·International Immunology·Connie L SommersLawrence E Samelson
Jan 4, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yanping GongSidong Xiong
Sep 2, 2011·Pharmacological Reviews·Vanesa Gabriela MartínezFrancisco Lozano
Jan 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maja MaricStanislav Vukmanovic
Sep 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yu QiaoCheong-Hee Chang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.