Finegoldia magna (formerly Peptostreptococcus magnus): an overlooked etiology for toxic shock syndrome?

Medical Hypotheses
Marnie E RosenthalElliot Frank

Abstract

Finegoldia magna is an anaerobic Gram positive coccus, previously classified as Peptostreoptococcus magnus. It is normal flora of the gastrointestinal and genitourinary tract, and can be isolated from skin and the oral cavity and is often regarded as a contaminant in cultures. As the most frequently isolated anaerobic coccus, it is implicated in a range of mono- and polymicrobial infections, including skin and skin structure, bone and joint (native and prosthetic joints), infective endocarditis (native and prosthetic valves), necrotizing pneumonia, mediastinitis and meningitis. Recently, whole genome sequencing furthered the understanding of the pathogenicity of this organism by elucidating both chromosomally encoded and mobile plasmid mediated virulence factors. Although no cases of toxic shock syndrome have been attributed to F. magna, we present a case of a fatal monomicrobial F. magna bacteremia and hypothesize that superantigen activity, mediated via Protein L binding the variable domain of the κ light chains of IgG, resulted in the syndrome observed in our patient. Additionally, we suspect the overall significance of this pathogen is underestimated and with more sensitive detection methods, this organism will be identifie...Continue Reading

References

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Citations

Oct 4, 2012·FEMS Microbiology Reviews·Elizabeth Carmel Murphy, Inga-Maria Frick
Dec 30, 2014·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Michael D DarleyTed R Mikuls
Apr 17, 2019·Environmental Microbiology·Emmanuel GonzalezNicholas J B Brereton
Sep 5, 2020·Genome Research·Hang Dai, Yongtao Guan
Dec 16, 2016·The Journal of Biological Chemistry·Martijn van RosmalenMaarten Merkx
Dec 22, 2017·Revista Do Instituto De Medicina Tropical De São Paulo·Jesús Rojas-JaimesMeredith Kerrigan
Dec 10, 2020·Computational and Structural Biotechnology Journal·Wendy Li, Zhanshan Sam Ma

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