Fingerprint changes in CSF composition associated with different aetiologies in human neonatal hydrocephalus: glial proteins associated with cell damage and loss

Fluids and Barriers of the CNS
Irum NaureenJaleel A Miyan

Abstract

In hydrocephalus an imbalance between production and absorption of cerebrospinal fluid (CSF) results in fluid accumulation, compression and stretching of the brain parenchyma. In addition, changes in CSF composition have a profound influence on the development and function of the brain and together, these can result in severe life-long neurological deficits. Brain damage or degenerative conditions can result in release of proteins expressed predominantly in neurons, astroglia, or oligodendroglia into the brain interstitial fluid, CSF and blood. Determination of such products in the CSF might be of value in diagnosing cause, aetiology and/or assessing the severity of the neurological damage in patients with hydrocephalus. We therefore analysed CSF from human neonates with hydrocephalus for these proteins to provide an insight into the pathophysiology associated with different aetiologies. CSF was collected during routine lumbar puncture or ventricular tap. Samples were categorized according to age of onset of hydrocephalus and presumed cause (fetal-onset, late-onset, post-haemorrhagic or spina bifida with hydrocephalus). Glial fibrillary acidic protein (GFAP), myelin basic protein (MBP), vimentin and 2' , 3'-cyclic nucleotide 3'...Continue Reading

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Citations

Jun 19, 2014·Fluids and Barriers of the CNS·Lester R DrewesRichard F Keep
Apr 16, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Irum NaureenJaleel A Miyan
Feb 18, 2017·PloS One·David D LimbrickDiego M Morales
Oct 27, 2018·Journal of Neuropathology and Experimental Neurology·María García-BonillaAntonio J Jiménez
Jan 1, 2015·Heart Failure Reviews·Wang ZhaoShui-Ping Zhao
Feb 2, 2021·Data in Brief·Jaspreet Kaur, Eller Conti

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Methods Mentioned

BETA
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Software Mentioned

Graphpad Prism
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