Fingolimod administration improves neurological functions of mice with subarachnoid hemorrhage.

Neuroscience Letters
Yi WangJianning Zhang

Abstract

To investigate the brain protective effects of fingolimod on inflammatory response of SAH mice. We utilized an endovascular mouse perforation model of SAH. Mice were divided into three groups: sham group, SAH group and SAH + Fingolimod group. Mice received either saline or fingolimod (1 mg/kg) intraperitoneally 2 h after sham surgery or SAH. The modified neurological severity score (mNSS) and Morris water maze were respectively used to evaluate the influence of nerve function. Evens blue (EB) extravasation was used to detect the permeability of blood-brain barrier, and water content in brain tissue was also detected. Flow cytometry, ELISA kits and western blotting were used to detect inflammatory factors in brain tissue. The results showed that compared with SAH group, after treatment, the delay time of locating the hidden platform was shorter. The mNSS results showed that fingolimod improved the behavior of SAH mice. In addition, fingolimod could reduce the water content in brain. Flow cytometry results showed that after 3 d of treatment, fingolimod significantly increased Treg cells and down-regulated NK cells. Western blotting results showed fingolimod inhibited the expression of inflammatory cytokines in brain tissue. ELISA...Continue Reading

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Citations

Nov 30, 2020·Experimental Neurology· Zeyu Zhang Sheng Chen
May 1, 2021·International Journal of Molecular Sciences·Matthias Simon, Alexander Grote
Jul 30, 2021·Brain Hemorrhages·Jingsong Ruan, Yao Yao
Aug 10, 2021·Frontiers in Neurology·Darcy LidingtonSteffen-Sebastian Bolz

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