Fingolimod as a Treatment in Neurologic Disorders Beyond Multiple Sclerosis.

Drugs in R&D
Pablo BascuñanaJens Pahnke

Abstract

Fingolimod is an approved treatment for relapsing-remitting multiple sclerosis (MS), and its properties in different pathways have raised interest in therapy research for other neurodegenerative diseases. Fingolimod is an agonist of sphingosine-1-phosphate (S1P) receptors. Its main pharmacologic effect is immunomodulation by lymphocyte homing, thereby reducing the numbers of T and B cells in circulation. Because of the ubiquitous expression of S1P receptors, other effects have also been described. Here, we review preclinical experiments evaluating the effects of treatment with fingolimod in neurodegenerative diseases other than MS, such as Alzheimer's disease or epilepsy. Fingolimod has shown neuroprotective effects in different animal models of neurodegenerative diseases, summarized here, correlating with increased brain-derived neurotrophic factor and improved disease phenotype (cognition and/or motor abilities). As expected, treatment also induced reductions in different neuroinflammatory markers because of not only inhibition of lymphocytes but also direct effects on astrocytes and microglia. Furthermore, fingolimod treatment exhibited additional effects for specific neurodegenerative disorders, such as reduction of amyloid...Continue Reading

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Citations

Feb 27, 2021·Frontiers in Immunology·Nienke M de WitGijs Kooij
Jun 3, 2021·International Journal of Environmental Research and Public Health·Maria LucaFrancesco Patti
Jul 3, 2021·International Journal of Molecular Sciences·Joanna A MotylRobert P Strosznajder
Aug 8, 2021·International Journal of Molecular Sciences·Bhakta Prasad Gaire, Ji-Woong Choi
Aug 28, 2021·Pharmacology & Therapeutics·Emanuela Colombo, Cinthia Farina

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Methods Mentioned

BETA
transgenic

Clinical Trials Mentioned

NCT02061137

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