Fingolimod's Impact on MRI Brain Volume Measures in Multiple Sclerosis: Results from MS-MRIUS

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Robert ZivadinovMS-MRIUS investigators

Abstract

Evidence is needed to understand the effect of fingolimod on slowing down brain atrophy progression in multiple sclerosis (MS) patients in clinical practice. We investigated the effect of fingolimod on brain atrophy in MS patients with active disease (clinically and/or magnetic resonance imaging [MRI]) versus no evidence of active disease (NEAD). MS and clinical outcome and MRI in the United States (MS-MRIUS) is a multicenter, retrospective study that included 590 relapsing-remitting MS patients, who initiated fingolimod, and were followed for a median of 16 months. Patients with active disease at baseline (245, 41.5%) were defined as those who had one or more relapses in the year previous starting fingolimod, and/or displayed gadolinium enhancing lesions(s) at baseline MRI scan, whereas patients with NEAD at baseline (345, 58.5%) did not fulfill these criteria. Annualized percentage brain volume change (PBVC) and percentage lateral ventricle volume change (PLVVC) over the follow-up were analyzed in both groups. Over the follow-up, the rate of PBVC was -.38% in active disease and -.25% in NEAD patients (P = .076), whereas PLLVC was 1.76% in active disease and .28% in NEAD patients (P = .046). No changes in timed 25-foot walk (P...Continue Reading

References

Jul 24, 2002·Brain : a Journal of Neurology·David H MillerAlan J Thompson
Dec 17, 2002·NeuroImage·Stephen M SmithNicola De Stefano
Jun 3, 2009·Nature Reviews. Neurology·Frederik BarkhofStephen C Reingold
Jun 16, 2009·Journal of Neuropathology and Experimental Neurology·Marco VercellinoPaola Cavalla
Jan 22, 2010·The New England Journal of Medicine·Ludwig KapposUNKNOWN FREEDOMS Study Group
Jan 22, 2010·The New England Journal of Medicine·Jeffrey A CohenUNKNOWN TRANSFORMS Study Group
Apr 27, 2011·Annals of Neurology·Jeffrey A Cohen, Jerold Chun
Mar 7, 2012·European Journal of Radiology·M MagranerB Casanova
Jul 4, 2012·Archives of Neurology·Ernst-Wilhelm RadueUNKNOWN FTY720 Research Evaluating Effects of Daily Oral Therapy in Multiple Sclerosis (FREEDOMS) Study Group
May 2, 2013·Journal of Neurology·Jeffrey A CohenGordon Francis
Jan 22, 2014·CNS Drugs·Nicola De StefanoBernd C Kieseier
May 30, 2014·Neurology·Fred D LublinChris H Polman
Apr 24, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T UherR Zivadinov
Jun 30, 2015·Current Medical Research and Opinion·T DerfussD L Tomic
Sep 9, 2015·Multiple Sclerosis and Related Disorders·Tjalf ZiemssenBernd C Kieseier
Dec 26, 2015·Journal of Neurology·Tjalf ZiemssenSven Schippling
Feb 18, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Robert ZivadinovDana Horakova
Apr 23, 2016·Expert Review of Neurotherapeutics·Robert ZivadinovNiels Bergsland
May 31, 2016·Multiple Sclerosis and Related Disorders·Nicola De StefanoMaria Pia Sormani
Dec 6, 2016·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Robert ZivadinovBianca Weinstock-Guttman
Mar 2, 2017·CNS Drugs·Nicola De StefanoMichael H Barnett
Jan 21, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·X MontalbanF Zipp
Mar 13, 2018·NeuroImage. Clinical·Michael G DwyerRobert Zivadinov

❮ Previous
Next ❯

Citations

Jun 21, 2020·International Journal of Molecular Sciences·Madeline BrossEvanthia Bernitsas
Dec 29, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Evanthia BernitsasFen Bao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
M SailerD H Miller
© 2022 Meta ULC. All rights reserved