PMID: 11310784Apr 20, 2001Paper

Finite element analysis of the current-density and electric field generated by metal microelectrodes

Annals of Biomedical Engineering
Cameron C McIntyre, Warren M Grill

Abstract

Electrical stimulation via implanted microelectrodes permits excitation of small, highly localized populations of neurons, and allows access to features of neuronal organization that are not accessible with larger electrodes implanted on the surface of the brain or spinal cord. As a result there are a wide range of potential applications for the use of microelectrodes in neural engineering. However, little is known about the current-density and electric field generated by microelectrodes. The objectives of this project were to answer three fundamental questions regarding electrical stimulation with metal microelectrodes using geometrically and electrically accurate finite elements models. First, what is the spatial distribution of the current density over the surface of the electrode? Second, how do alterations in the electrode geometry effect neural excitation? Third, under what conditions can an electrode of finite size be modeled as a point source? Analysis of the models showed that the current density was concentrated at the tip of the microelectrode and at the electrode-insulation interface. Changing the surface area of the electrode, radius of curvature of the electrode tip, or applying a resistive coating to the electrod...Continue Reading

Citations

Jun 29, 2005·Annals of Biomedical Engineering·Dongchul C Lee, Warren M Grill
Mar 24, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Cameron C McIntyreJerrold L Vitek
Jul 10, 2009·Journal of Neural Engineering·Xuefeng F Wei, Warren M Grill
Jun 13, 2014·PloS One·Erik W SchluterBruno B Averbeck
Jun 26, 2004·The Journal of Physiology·Trent AndersonZelma H T Kiss
Nov 1, 2011·Journal of Physiology, Paris·Sébastien Joucla, Blaise Yvert
Apr 26, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Cristian DonosAndrei Barborica
Jun 30, 2009·Progress in Neurobiology·Paolo GubelliniChristelle Baunez
Nov 24, 2007·Neuroscience and Biobehavioral Reviews·Jing-Yu ChangDonald J Woodward
Apr 20, 2007·Neuroscience and Biobehavioral Reviews·Jing-Yu ChangDonald J Woodward
Mar 31, 2015·Neuroinformatics·Torbjørn V NessGaute T Einevoll
Jul 23, 2014·IEEE Transactions on Bio-medical Engineering·Boshuo WangJames D Weiland
May 25, 2005·Journal of Neuroscience Methods·Bogdan NeaguDavid O Carpenter
Jul 3, 2007·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Mesut Sahin, Syed S Ur-Rahman
Jul 2, 2009·IEEE Transactions on Bio-medical Engineering·Yvonne SticklerFrank Rattay
Oct 3, 2006·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Jeng-Shyong ShyuMark S Humayun
Apr 11, 2006·IEEE Transactions on Bio-medical Engineering·Douglas McCreeryXindong Liu
Aug 25, 2004·Journal of Neuroscience Methods·Daniel A WagenaarSteve M Potter
Aug 30, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Christopher R Butson, Cameron C McIntyre
Mar 1, 2012·Epilepsy & Behavior : E&B·Daniel de Castro MedeirosMárcio Flávio Dutra Moraes
Nov 4, 2010·Progress in Biophysics and Molecular Biology·Michel Bernanos Soares MesquitaMárcio Flávio Dutra Moraes
Jun 3, 2016·Computers in Biology and Medicine·Wenyan JiaMingui Sun
Jul 26, 2016·Frontiers in Neuroscience·Paolo MassobrioSergio Martinoia
Aug 24, 2016·ELife·Sébastien RouxFrédéric Chavane
Nov 1, 2016·Science Translational Medicine·Emily L GraczykDustin J Tyler
Feb 3, 2018·Stereotactic and Functional Neurosurgery·Jeffrey E ArleJay L Shils
Dec 12, 2003·Journal of Neurophysiology·Cameron C McIntyreNitish V Thakor
Aug 22, 2018·Journal of Neural Engineering·Aman S AberraWarren M Grill
Jul 1, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Robert E GrossAlim-Louis Benabid
Mar 4, 2008·Journal of Neural Engineering·Donald R CantrellJohn B Troy
Mar 4, 2008·Journal of Neural Engineering·Chad A BossettiWarren M Grill
Feb 6, 2009·Journal of Neurophysiology·Shelley I FriedJoseph F Rizzo
Jan 9, 2015·Annals of Biomedical Engineering·SiCong ChenXiaoXiang Zheng

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