Finite element analysis of vulnerable atherosclerotic plaques: a comparison of mechanical stresses within carotid plaques of acute and recently symptomatic patients with carotid artery disease.

Journal of Neurology, Neurosurgery, and Psychiatry
Umar SadatJonathan H Gillard

Abstract

There is considerable evidence that patients with carotid artery stenosis treated immediately after the ischaemic cerebrovascular event have a better clinical outcome than those who have delayed treatment. Biomechanical assessment of carotid plaques using high-resolution MRI can help examine the relationship between the timing of carotid plaque symptomology and maximum simulated plaque stress concentration. Fifty patients underwent high-resolution multisequence in vivo MRI of their carotid arteries. Patients with acute symptoms (n=25) underwent MRI within 72 h of the onset of ischaemic cerebrovascular symptoms, whereas recently symptomatic patients (n=25) underwent MRI from 2 to 6 weeks after the onset of symptoms. Stress analysis was performed based on the geometry derived from in vivo MRI of the symptomatic carotid artery at the point of maximum stenosis. The peak stresses within the plaques of the two groups were compared. Patient demographics were comparable for both groups. All the patients in the recently symptomatic group had severe carotid stenosis in contrast to patients with acute symptoms who had predominantly mild to moderate carotid stenosis. The simulated maximum stresses in patients with acute symptoms was signif...Continue Reading

Citations

Apr 18, 2012·European Heart Journal·Paolo G CamiciPeter Libby
Aug 6, 2013·IEEE Transactions on Bio-medical Engineering· Zhongzhao TengJonathan H Gillard
Jun 6, 2012·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Oberdan ParodiNenad Filipovic
Aug 9, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ammara UsmanJonathan H Gillard
Feb 5, 2014·Journal of Biomechanics·Gerhard A HolzapfelMichael T Walsh
Apr 1, 2015·The British Journal of Radiology·G C MakrisJ H Gillard
Jun 7, 2011·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Z TengJ H Gillard
Sep 14, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Chengcheng ZhuJonathan H Gillard
Feb 9, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Umar SadatJonathan H Gillard
Oct 19, 2013·Experimental and Therapeutic Medicine·Baojun WangXiue Li
May 28, 2019·Bio-medical Materials and Engineering·Achmad SyaifudinKatsuhiko Sasaki
Mar 9, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Hideaki Yoshino

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