Abstract
DNA damage is recognized as a central component of carcinogenesis. DNA-damaging agents activate a number of signal transduction pathways that lead to repair of the DNA, apoptosis, or cell cycle arrest. It is reasoned that a cell deficient in DNA repair is more likely to acquire other cancer-promoting mutations. Despite the recent interest in the link between DNA damage and carcinogenesis, retroviral oncogenes have not yet been shown to affect the DNA damage-signaling pathway. In this report, we show that Finkel-Biskis-Reilly mouse osteosarcoma virus (FBR) v-fos, the retroviral homologue of the c-fos proto-oncogene, inhibits the cellular response to ionizing radiation. Cells that express FBR v-Fos show a decreased ability to repair DNA damage caused by ionizing radiation, and these cells show decreased survival in response to ionizing radiation. In addition, FBR v-Fos inhibits DNA-dependent protein kinase, a kinase specifically activated upon exposure to ionizing radiation. These effects were specific to ionizing radiation, as no effect of FBR v-Fos on the UV light signaling pathway was seen. Last, these effects were dependent on a lipid modification required for FBR v-Fos tumorigenesis, that of myristoylation of FBR v-Fos. A no...Continue Reading
References
Feb 1, 1992·Molecular and Cellular Biology·N Kamata, J T Holt
Nov 1, 1992·Molecular and Cellular Biology·S P Lees-MillerC W Anderson
Feb 1, 1991·Molecular and Cellular Biology·N KamataJ T Holt
Aug 1, 1991·The Journal of Clinical Investigation·M A BrachD Kufe
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D E HallahanR R Weichselbaum
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M L ShermanD W Kufe
Mar 2, 1990·Science·K T JeangS H Wilson
Dec 9, 1988·Science·L D KerrL M Matrisian
May 1, 1984·Virology·T Curran, I M Verma
Sep 1, 1982·Molecular and Cellular Biology·C M GormanB H Howard
Aug 11, 1995·The Journal of Biological Chemistry·S KharbandaJ Kyriakis
Mar 1, 1995·Genes & Development·Z Q WangE F Wagner
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·N J FinnieS P Jackson
Feb 24, 1995·Science·S P Lees-MillerJ Allalunis-Turner
Mar 10, 1995·Cell·T BluntS P Jackson
Mar 15, 1994·Genes & Development·A E WhiteT D Tlsty
Oct 14, 1994·Science·V SmiderG Chu
Sep 2, 1994·Science·G E TaccioliP A Jeggo
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·S KharbandaD Kufe
Dec 3, 1993·Cell·R FishelR Kolodner
Dec 17, 1993·Cell·F S LeachM Nyström-Lahti
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·F M UckunC W Song
Apr 1, 1996·Molecular and Cellular Biology·A ErramiG Chu
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·S KharbandaD Kufe
Jul 18, 1996·Nature·Z M YuanD Kufe
Aug 29, 1996·Nature·U KasidT W Sturgill
Jan 1, 1996·Current Topics in Microbiology and Immunology·C W Anderson, T H Carter
Oct 1, 1996·The Journal of Cell Biology·R M Jotte, J T Holt
Feb 1, 1997·Molecular and Cellular Biology·M FunkR Müller
Citations
Apr 11, 2001·Biochimie·C AcquavivaM Piechaczyk
Jul 17, 1998·Journal of the National Cancer Institute·D W AbbottJ T Holt
Dec 18, 2002·Annals of the New York Academy of Sciences·Claire AcquavivaMarc Piechaczyk
Jul 19, 2006·Progress in Lipid Research·Ponniah SelvakumarRajendra K Sharma
Apr 21, 2001·Oncogene·C AcquavivaI Jariel-Encontre
Jan 23, 1999·The Journal of Biological Chemistry·D W Abbott, J T Holt
Jan 24, 1998·The Journal of Biological Chemistry·D W Abbott, J T Holt
Jun 22, 1999·The Journal of Biological Chemistry·D W AbbottJ T Holt
Mar 5, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Chang-Lin WuJing-Gung Chung
Sep 17, 2009·Molecular and Cellular Biochemistry·Rong ZhengDavid M Nanus
Sep 6, 2002·Biochemical Pharmacology·Claire AcquavivaMarc Piechaczyk