Apr 3, 2020

Structural basis to design multi-epitope vaccines against Novel Coronavirus 19 (COVID19) infection, the ongoing pandemic emergency: an in silico approach

BioRxiv : the Preprint Server for Biology
Sukrit SrivastavaM. Kolbe

Abstract

The 2019 novel coronavirus (COVID19 / Wuhan coronavirus), officially named as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2), is a positive sense single stranded RNA coronavirus. SARS CoV 2 causes the contagious COVID19 disease also known as 2019 nCoV acute respiratory disease and has led to the ongoing 2019-20 pandemic COVID19 outbreak. The effective countermeasures against SARS CoV 2 infection requires the design and development of specific and effective vaccine candidate. In the present study we have screened 38 CTL, 42 HTL and 12 B cell epitopes by utilizing different in silico tools. The screened epitopes were further validated for their binding with their respective HLA allele binders and TAP (Transporter associated with antigen processing) molecule by molecular docking. The screened epitopes were further utilized to design novel two multi epitope vaccines (MEVs) composed of CTL, HTL and B cell epitopes overlaps with potential to elicit humoral as well as cellular immune response against SARS CoV 2. To enhance the immune response for our vaccine design, truncated (residues 10 153) Onchocerca volvulus activation associated secreted protein 1 (Ov ASP 1) has been utilized as an adjuvant at N terminal of both th...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Genome-Wide Association Study
Study
Size
Genome
Schizophrenia
Stents, Vascular, Coronary
palmitoyl glycol chitosan
Psychiatry Specialty
Deep Sequencing
Genome Scan

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.