Abstract
Unitary extracellular recordings were made in in vitro rat brain slices to explore the effects of serotoninergic analogues on the spontaneous activity of substantia nigra reticulata (SNr) neurons. Most SNr neurons exhibited regular spontaneous firing (23.4 +/- 8.9 Hz, mean +/- S.E.M., n = 30) similar to that found in vivo. The most reproducible effect of serotonin (5-HT) was an increase in firing frequency found in 53% of the cells. The effect was concentration dependent and blocked by the 5-HT1/2 antagonist methysergide (1-10 microM) but unaffected by the 5-HT4- and 5-HT1-preferring antagonists DAU 6285 (5 microM) and metiothepin (5 microM), respectively. However, 5-HT also decreased the firing frequency in several neurons. In 19% of the neurons an inhibition was found alone but a biphasic response (inhibition and excitation) was found in another 28% of the neurons. Interestingly, the effect of the 5-HT-uptake inhibitor, duloxetine (100-400 nM), was frequency inhibition. Agonists that mimicked the 5-HT-induced inhibition were of the 5-HT1B-class (25 microM CP 93129 and 25 microM TFMPP). Neither the 5-HT2-antagonist ritanserin (5 microM) nor the GABA(A)-antagonist, bicuculline (30 microM) were able to block the inhibition sugge...Continue Reading
References
Aug 13, 1976·Brain Research·E RinvikO P Ottersen
Apr 15, 1977·The Journal of Comparative Neurology·J M JuraskaP M Groves
Jul 7, 1978·Brain Research·P G Guyenet, G K Aghajanian
Jul 28, 1978·Brain Research·S R VincentE G McGeer
Aug 17, 1979·Brain Research·C FrancoisS Heyner
Nov 11, 1977·Brain Research·C J WilsonP M Groves
Nov 1, 1991·Synapse·P W Sheldon, G K Aghajanian
Jan 1, 1989·Synapse·G K Aghajanian, K Rasmussen
Jan 1, 1987·Anatomy and Embryology·S MoriY Sano
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
May 17, 1973·Brain Research·T HattoriE G McGeer
Sep 1, 1974·The Journal of Comparative Neurology·M Palkovits, D M Jacobowitz
May 18, 1981·Brain Research·G L Collingridge, J Davies
Jan 1, 1982·Experimental Brain Research·J M DeniauI Grofova
Jan 1, 1982·Neuroscience·I C KilpatrickM S Starr
Jul 10, 1982·The Journal of Comparative Neurology·I GrofovaS T Kitai
Jun 8, 1981·Life Sciences·C OberlanderJ R Boissier
Jun 1, 1995·Journal of Neuroscience Methods·P LiptonP M Larkman
Jul 1, 1993·Neuroscience·N CorvajaJ P Bolam
Oct 3, 1994·Brain Research·C E Rick, M G Lacey
Jul 1, 1993·British Journal of Pharmacology·C J GrossmanK T Bunce
Dec 1, 1995·Neuroscience·C E RickM G Lacey
Jan 1, 1996·Behavioural Brain Research·D Hoyer, G R Martin
Jan 1, 1986·Neurochemistry International·D WeissmannJ F Pujol
Citations
Feb 13, 2001·Biological Psychiatry·J K ZubietaK A Frey
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·José L Bata-GarcíaJosé L Góngora-Alfaro
Apr 26, 2013·Experimental Brain Research·P De DeurwaerdèreS Navailles
Dec 6, 2011·Neuroscience·C DelavilleA Benazzouz
Dec 8, 2004·Journal of Psychiatric Practice·Sheldon H Preskorn
Aug 24, 2007·Journal of Neurophysiology·Osvaldo Ibáñez-SandovalJosé Bargas