Firing patterns and synchronization in nonsynaptic epileptiform activity: the effect of gap junctions modulated by potassium accumulation

Physical Biology
D O C SantosR Dickman

Abstract

Several lines of evidence point to the modification of firing patterns and of synchronization due to gap junctions (GJs) as having a role in the establishment of epileptiform activity (EA). However, previous studies consider GJs as ohmic resistors, ignoring the effects of intense variations in ionic concentration known to occur during seizures. In addition to GJs, extracellular potassium is regarded as a further important factor involved in seizure initiation and sustainment. To analyze how these two mechanisms act together to shape firing and synchronization, we use a detailed computational model for in vitro high-K(+) and low-Ca(2+) nonsynaptic EA. The model permits us to explore the modulation of electrotonic interactions under ionic concentration changes caused by electrodiffusion in the extracellular space, altered by tortuosity. In addition, we investigate the special case of null GJ current. Increased electrotonic interaction alters bursts and action potential frequencies, favoring synchronization. The particularities of pattern changes depend on the tortuosity and array size. Extracellular potassium accumulation alone modifies firing and synchronization when the GJ coupling is null.

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A Sherman, J Rinzel
Mar 1, 1991·Biophysical Journal·A Sherman, J Rinzel
Feb 1, 2000·Trends in Neurosciences·J L Perez Velazquez, P L Carlen
Aug 10, 2000·Neural Computation·C C Chow, N Kopell
Jan 11, 2002·Journal of Neurophysiology·Marom BiksonDominique M Durand
Jun 13, 2003·Journal of Neurophysiology·Marom BiksonJohn G R Jefferys
Feb 6, 2004·Journal of Consulting and Clinical Psychology·Ana F Abraído-LanzaSandra E Echeverría
Feb 6, 2004·Best Practice & Research. Clinical Anaesthesiology·Ignatius Y Tang, Patrick T Murray
Mar 23, 2004·Biochimica Et Biophysica Acta·Sheriar G HormuzdiRoberto Bruzzone
Feb 1, 2006·Journal of Neuroscience Methods·M ChavezJ Martinerie
May 12, 2006·International Journal of Neural Systems·Dmitry E PostnovOlga V Sosnovtseva
Oct 21, 2006·Journal of Computational Neuroscience·H KagerG G Somjen
Aug 7, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Oliver Weihberger, Sonya Bahar
Sep 4, 2007·Progress in Brain Research·F Edward Dudek, Thomas P Sutula
Feb 26, 2008·Journal of Computational Neuroscience·G G SomjenW J Wadman
Apr 29, 2008·Biophysical Journal·Eun-Hyoung ParkDominique M Durand
Jul 18, 2008·Social Neuroscience·Lindsay M ObermanVilayanur S Ramachandran
Oct 17, 2008·Physiological Reviews·Eva Syková, Charles Nicholson
Nov 11, 2008·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Flavio FröhlichTerrence J Sejnowski

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Citations

Dec 21, 2010·Epilepsy & Behavior : E&B·Antônio-Carlos G AlmeidaJaderson C DaCosta
Oct 5, 2013·Physical Biology·Mariana Rodrigues LopesAntônio-Carlos Guimarães de Almeida
Mar 15, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Xing-Xing Wu, Jianwei Shuai

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