Firing patterns of accumbal neurons during a pavlovian-conditioned approach task

Journal of Neurophysiology
Xun Wan, Laura L Peoples

Abstract

The nucleus accumbens (NAc) is necessary for the expression of Pavlovian-conditioned approach behavior but not for the expression of instrumental behavior conditioned in sessions that set a low response requirement. Although numerous studies have characterized firing patterns of NAc neurons in relation to instrumental behavior, very little is known about how NAc neurons encode information in Pavlovian tasks. In the present study, recordings of accumbal firing patterns were made during sessions in which rats performed a Pavlovian-conditioned approach task. Most of the recorded neurons (74/83, 89%) exhibited significant responses during the conditioned stimulus (CS) presentation and/or the reward exposure. The reward responses were prevalent, predominantly inhibitory, and comparable to reward responses observed in various types of behavioral paradigms, including instrumental tasks. The CS responses could be segregated into multiple subtypes on the basis of directionality, onset latency, and duration. Several characteristics of the CS firing patterns were unique relative to cue responses observed previously during alternative types of conditioning sessions. It is possible that the novel firing patterns correspond to the differenti...Continue Reading

References

Jan 1, 1991·Experimental Brain Research·P ApicellaW Schultz
Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
Dec 15, 1994·Behavioural Brain Research·B Balleine, S Killcross
Jun 30, 1993·Behavioural Brain Research·G V WilliamsC Stern
Aug 15, 1998·Journal of Neurophysiology·J R HollermanW Schultz
Aug 28, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·P Di Ciano, B J Everitt
Apr 27, 2002·Experimental Brain Research·R de BorchgraveB W Balleine
May 30, 2002·Neuroscience and Biobehavioral Reviews·Rudolf N CardinalBarry J Everitt
Mar 4, 2003·Journal of Neurophysiology·Howard C Cromwell, Wolfram Schultz
May 27, 2003·Neuron·Barry SetlowMichela Gallagher
Oct 3, 2003·Journal of Neurophysiology·Laura L PeoplesNidhi Gangadhar
Apr 15, 2004·Current Opinion in Neurobiology·Rudolf N Cardinal, Barry J Everitt
Jan 22, 2005·Current Opinion in Pharmacology·J D SalamoneS M Weber
Feb 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sharif A Taha, Howard L Fields
Apr 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey W DalleyTrevor W Robbins
Mar 24, 2006·The European Journal of Neuroscience·Jeremy J DayRegina M Carelli

❮ Previous
Next ❯

Citations

Mar 4, 2008·Psychopharmacology·Kent C Berridge, Morten L Kringelbach
Jun 12, 2013·Neuropharmacology·Terry E RobinsonBenjamin T Saunders
Mar 23, 2007·Annual Review of Neuroscience·Howard L FieldsSaleem M Nicola
Apr 4, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jeremy J Day, Regina M Carelli
May 9, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Akinori IshikawaHoward L Fields
Nov 10, 2009·Cognitive, Affective & Behavioral Neuroscience·Tiago V Maia
Sep 1, 2007·The Journal of Physiology·Sharif A TahaHoward L Fields
Jan 5, 2011·The European Journal of Neuroscience·Jeremy J DayRegina M Carelli
Sep 28, 2016·ELife·Susana S CorreiaKi A Goosens
Aug 11, 2017·Journal of Neurophysiology·Sara E MorrisonSaleem M Nicola
Sep 6, 2019·ELife·Bernadette O'DonovanPavel I Ortinski
Apr 14, 2021·Neuroscience and Biobehavioral Reviews·Hannah S Wirtshafter, Matthew A Wilson
Aug 10, 2021·Frontiers in Human Neuroscience·Ayse Ilkay Isik, Edward A Vessel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.