PMID: 9447927Feb 3, 1998Paper

Firing properties of spherical bushy cells in the anteroventral cochlear nucleus of the gerbil

Hearing Research
D W Schwarz, E Puil

Abstract

In gerbils, spherical bushy cells (SBCs) encode low frequency sound signals into a temporal firing pattern. To investigate the support for the timing in this temporal code, we characterized the membrane electrical properties of visually identified SBCs in brainstem slices. A brief depolarizing subthreshold transient potential (TP) triggered, with relatively invariant latency, a single spike at the onset of a response to depolarizing current pulses. The activation of a subthreshold Na+-conductance, sensitive to blockade with tetrodotoxin, and a high threshold Ca2+-conductance, sensitive to blockade with Co2+ or Cd2+, accelerated the rising phase and amplified the TP. A K+-conductance, sensitive to blockade by 4-aminopyridine (4-AP, 50 microM), shaped the decay of the TP. Following a single spike, voltage-gated activation of transient and sustained K+-conductances suppressed any tendency to repetitively discharge. A reduction in either K+-conductance due to application of 4-AP or tetraethylammonium (TEA, 10 mM), converted the single spike mode to repetitive firing during the depolarizing pulses. A persistent, tetrodotoxin-sensitive Na+-conductance amplified steady-state depolarizing responses. A hyperpolarization-activated conduc...Continue Reading

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Citations

Mar 12, 2009·Journal of the Association for Research in Otolaryngology : JARO·Ramazan Bal, Giyasettin Baydas
Oct 10, 2002·Hearing Research·Catherine M McMahon, Robert B Patuzzi
Sep 19, 2003·Hearing Research·Aasef G Shaikh, Paul G Finlayson
Feb 8, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Zoltán RusznákGéza Szucs
Nov 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew H HiggsWilliam J Spain
Feb 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luisa L ScottNace L Golding
Mar 3, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ning-ying SongShan-kai Yin
Jul 11, 2012·The European Journal of Neuroscience·Crawford I P Winlove, Alan Roberts
Dec 20, 2002·Acta Physiologica Hungarica·G Szucs, Z Rusznák
Jul 21, 2009·Hearing Research·Ramazan BalMustafa Naziroglu
Jun 5, 2003·Journal of Neurophysiology·Jason S Rothman, Paul B Manis
Jun 5, 2003·Journal of Neurophysiology·Jason S Rothman, Paul B Manis
Apr 13, 2007·Journal of Neurophysiology·Xiao-Jie CaoDonata Oertel
May 18, 2007·Journal of Neurophysiology·Joachim HermannAchim Klug
Aug 10, 2007·Journal of Neurophysiology·Sungchil Yang, Albert S Feng
Jul 3, 2009·Journal of Neurophysiology·Ivan MilenkovicRudolf Rübsamen
Feb 23, 2021·Frontiers in Neuroscience·Jing Wu, Leonard K Kaczmarek

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