PMID: 9430243Jan 16, 1998Paper

First- and second-year effects in trials of calcium supplementation on the loss of bone density in postmenopausal women

Bone
D Mackerras, T Lumley

Abstract

The analysis of clinical trials investigating the effect of calcium on the loss of bone mass or density has been based on the assumption that the effects are the same for all years of follow-up. Hence the average annual rate of loss is calculated and compared in the calcium and control groups. In this metaanalysis, we investigated this assumption and found that it is not tenable in the groups randomized to calcium for most sites that have been measured. The rate of bone loss was significantly less in the first year after randomization than in the second year. By contrast, the rate of loss in the control groups was less in the second year than the first, although this was not significant. At the spine, femoral neck, trochanter, intertrochanter, midtibia, and ultratibia, the effect of calcium in reducing bone loss was statistically significant compared with control only in the first year after randomization; there was no difference in rates between the groups in the second year. The effect of calcium compared to control in two arm sites and Ward's triangle was of a similar magnitude but was not statistically significant. We recommend that analysis and metaanalysis of trials should always consider the effects on a year-by-year basis.

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Citations

Nov 14, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J W NievesY T Chen
Jan 29, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J F AloiaJ K Yeh
Jul 30, 2009·Wiener medizinische Wochenschrift. Supplement·Hans Peter DimaiUNKNOWN Austrian Society for Bone and Mineral Research (AuSBMR)
May 2, 2009·Menopause : the Journal of the North American Menopause Society·Camil Castelo-BrancoLluís Pérez-Edo
Feb 27, 2009·The American Journal of Clinical Nutrition·Mei ChungJoseph Lau
Mar 10, 2009·Nutrition·Karl Michaelsson
May 21, 2013·Food & Nutrition Research·Kirsti Uusi-RasiChristel J E Lamberg-Allardt
Jul 20, 2007·The Cochrane Database of Systematic Reviews·B SheaUNKNOWN Osteoporosis Research Advisory Group
Aug 31, 2002·Endocrine Reviews·Beverley SheaUNKNOWN Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group
Apr 12, 2013·Periodontology 2000·Robert J Genco, Wenche S Borgnakke
May 21, 2003·Periodontology 2000·Nico C GeursMarjorie K Jeffcoat
Oct 18, 2000·The Cochrane Database of Systematic Reviews·D HaguenauerG Wells
Sep 8, 2007·The American Journal of Clinical Nutrition·Massimo VarennaLuigi Sinigaglia
May 11, 2005·The American Journal of Clinical Nutrition·Jeri W Nieves
Mar 28, 2019·Aging Clinical and Experimental Research·Manju ChandranAmbrish Mithal

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