First acute rejection episode after renal transplantation: study of the histopathological characteristics according to the immunological risk

Néphrologie & thérapeutique
Lidia GhisdalDaniel Abramowicz

Abstract

Renal allograft biopsies (n=34) of two different populations of patients according to the immunological risk (high versus low-risk) have been compared retrospectively. The presence of polymorphonuclear leukocytes in peritubular capillaries was more frequent in the high-risk group. The C4d staining was positive in 10% of the low-risk patients and in 50% of the high-risk patients (P=0.03). There were more early graft loss, renal infarctions, interstitial hemorrhage, severe glomerulitis, neutrophilic glomerulitis and Banff III grade rejection in the positive C4d group. In conclusion, half of the immunized patients had a humoral rejection, patients with a C4d positive rejection had more early graft loss and more severe histological lesions.

References

Feb 13, 1999·Kidney International·L C RacusenY Yamaguchi
Sep 27, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H RegeleG A Böhmig
Oct 25, 2001·Journal of the American Society of Nephrology : JASN·Georg A BöhmigBruno Watschinger
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·Volker NickeleitM J Mihatsch
Feb 22, 2002·Journal of the American Society of Nephrology : JASN·Shamila MauiyyediRobert B Colvin
Dec 14, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kevin C MangeHarold I Feldman
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Helmut E Feucht
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Lorraine C RacusenKiril Trpkov
Jun 12, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Luis M Pallardó MateuAntonio Franco Esteve
Feb 11, 2005·The New England Journal of Medicine·Duska DragunGerd Wallukat
May 4, 2005·Human Immunology·Junchao Cai, Paul I Terasaki
Aug 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kazuo MizutaniJarhow Lee
Oct 28, 2005·Transplantation·Gabriel M Danovitch

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Citations

Jan 14, 2011·Néphrologie & thérapeutique·Chehrazade BrickMalika Essakalli

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