Abstract
China has a very high tuberculosis (TB) burden. The interferon-gamma release assay (IGRA) is more specific for the diagnosis of latent tuberculosis infection (LTBI) than the tuberculin skin test, especially among populations with a high degree of coverage by the BCG vaccine. To evaluate the first screening of healthcare workers (HCW) for LTBI using the IGRA at a general hospital in Beijing. A pilot screening program for LTBI was triggered by accidental contact between HCW and two patients with active TB in the emergency department (ED). Given the necessity of estimating the overall LTBI prevalence in the institution, a sample of 518 HCW was enrolled in our cross-sectional study. The second IGRA was repeated with 43 of the 121 HCW in the ED after exposure to index TB cases. Data on putative risk factors were collected with a self-administered questionnaire. The prevalence of LTBI in the targeted population was 21.8%. Differences in the prevalence of LTBI were significantly related to age, employment duration, and history of occupational exposure. A lack of childhood BCG vaccination was independently associated with the prevalence of LTBI (adjusted OR: 1.686, 95% CI: 1.045-2.723, P = .0325). No new LTBI was diagnosed 12 weeks pos...Continue Reading
References
Dec 30, 2006·PLoS Medicine·Rajnish JoshiMadhukar Pai
Jan 6, 2011·The European Respiratory Journal·L AnibarroA González-Fernández
Apr 5, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Victor HerreraNiaz Banaei
Mar 29, 2013·PloS One·Jennifer A WhitakerHenry M Blumberg
Sep 12, 2013·Health Technology Assessment : HTA·I AbubakarL C Rodrigues
Dec 5, 2013·Vaccine·Swati SinghSadhna Sharma
Dec 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Punam MangtaniJonathan A Sterne
Feb 15, 2015·The Lancet Infectious Diseases·Lei GaoUNKNOWN LATENTTB-NSTM study team
May 29, 2015·The New England Journal of Medicine·Haileyesus GetahunMario Raviglione
Oct 28, 2015·PloS One·Cheng ChenWei Lu
Jun 10, 2016·Journal of Occupational Medicine and Toxicology·Raffaela OlivieriDonata Medaglini
Oct 7, 2016·PloS One·Sharifa NasreenMonali S Malvankar-Mehta
Oct 26, 2016·PLoS Medicine·Rein M G J Houben, Peter J Dodd
Mar 4, 2017·La Presse médicale·Ruvandhi R NathavitharanaAlimuddin Zumla
Mar 25, 2017·BioMed Research International·Christian NapoliGiovanni Battista Orsi
Apr 7, 2017·Internal Medicine·Masaki TanabeMasaaki Ito
Apr 17, 2017·The Lancet Infectious Diseases·Shigui YangLanjuan Li
Jul 18, 2017·Journal of Immunology Research·Kai Ling ChinArmando Acosta
Sep 7, 2017·Open Forum Infectious Diseases·Lydia UdenGraham S Cooke
Sep 29, 2017·Frontiers in Immunology·Hazel M Dockrell, Steven G Smith
Oct 14, 2017·The Clinical Respiratory Journal·Tulin CagatayZeki Kılıçaslan
Jan 30, 2018·Frontiers in Immunology·Helder Novais BastosMargarida Saraiva