First asymmetric total syntheses of cernuane-type Lycopodium alkaloids, cernuine, and cermizine D

Organic Letters
Yasuhiro NishikawaHiromitsu Takayama

Abstract

The first total syntheses of two cernuane-type Lycopodium alkaloids, (-)-cernuine and (+)-cermizine D, were accomplished starting from (+)-citronellal. The syntheses involved organocatalytic alpha-amination to afford oxazolidinone, which is used for diastereoselective allylation, and asymmetric transfer aminoallylation followed by stereoselective construction of an aminal moiety as key steps.

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