First case of 18F-FACBC PET/CT-guided salvage retroperitoneal lymph node dissection for disease relapse after radical prostatectomy for prostate cancer and negative 11C-choline PET/CT: new imaging techniques may expand pioneering approaches

Urologia Internationalis
Riccardo SchiavinaGiuseppe Martorana

Abstract

We present the first case of salvage retroperitoneal lymph node dissection based on the results of (18)F-FACBC PET/CT performed for a prostate-specific antigen relapse after radical prostatectomy. The patients underwent (11)C-choline PET/CT, which turned out negative, while (18)F-FACBC PET/CT visualized two lymph node metastases confirmed at pathological examination. Preliminary clinical reports showed an improvement in the detection rate of 20-40% for (18)F-FACBC in comparison with (11)C-choline, rendering the (18)F-FACBC the potential radiotracer of the future. Salvage surgery for prostate cancer is a fascinating but controversial approach. New diagnostic tools may improve its potential by increasing the assessment and the selection of the patients.

Citations

Dec 19, 2015·Der Urologe. Ausg. A·D K OsmonovK-P Jünemann
Oct 19, 2016·World Journal of Urology·Elena IncertiMaria Picchio
Apr 5, 2014·Der Urologe. Ausg. A·T MaurerB J Krause
Sep 28, 2017·Oncotarget·Yiqiang QiShuanghu Yuan
Oct 25, 2016·Nuclear Medicine Communications·Laura EvangelistaVal Lowe
Feb 26, 2015·Current Opinion in Oncology·Kirsten BouchelouchePeter L Choyke
Jul 17, 2021·Seminars in Nuclear Medicine·Riccardo MeiStefano Fanti

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