First case of drug rash eosinophilia and systemic symptoms due to boceprevir

Journal of Hepatology
Agnès SamainGhassan Riachi

Abstract

Boceprevir and telaprevir are 2 specific inhibitors of the hepatitis C (HCV) serine protease 3. Cutaneous side effects have been reported with high frequency, essentially rash, and dry skin. We report a case of drug rash with eosinophilia and systemic symptoms (DRESS) due to boceprevir. A 56-year-old African woman with chronic hepatitis C complicated with cirrhosis and cryoglobulinemia received pegylated interferon alfa-2a (PegIFN) and ribavirin (RBV) for 4 weeks and then boceprevir was added. She was also co-infected with HIV state A2. Eight weeks after adding boceprevir she developed a generalized maculopapular exanthema with fever, facial oedema, apparition of lymph node and alteration of the general state. She presented an eosinophilia (up to 3.0 × 10(9)cells/L), no biological inflammatory syndrome. The computed tomography revealed several lymph nodes located in the abdominal and inguinal areas. The cutaneous biopsy was consistent with a drug rash reaction. The HCV treatment was stopped and the patient was treated with topical steroids. Cutaneous and systemic symptoms disappeared in few weeks. Boceprevir was considered the culprit drug. We report to our knowledge the first case of DRESS due to boceprevir.

References

Nov 18, 1993·The New England Journal of Medicine·L C Krop, D P Johnson
Mar 16, 2005·Toxicology·Jean-Claude Roujeau
Aug 28, 2010·Dermatology : International Journal for Clinical and Investigative Dermatology·H MontaudiéJ P Lacour
Apr 1, 2011·The New England Journal of Medicine·Fred PoordadUNKNOWN SPRINT-2 Investigators
May 20, 2011·The American Journal of Medicine·Patrice CacoubJean Claude Roujeau
May 23, 2012·Cutis·Justin S GordonSuephy C Chen
Jul 19, 2012·Scandinavian Journal of Infectious Diseases·Pierre Loulergue, Olivier Mir
Dec 20, 2012·Therapeutic Advances in Chronic Disease·Antonio Ascione
Feb 26, 2013·Médecine et maladies infectieuses·E S Bayonne Kombo, A Gathse

❮ Previous
Next ❯

Citations

Jul 16, 2014·Immunology and Allergy Clinics of North America·Brigitte Milpied-HomsiElizabeth J Phillips
Nov 24, 2016·Expert Opinion on Drug Safety·Cristina ScavoneAnnalisa Capuano
Mar 10, 2018·Hospital Practice·Sapan Kumar BeheraSandhiya Selvarajan
Jun 10, 2017·International Journal of Molecular Sciences·Yung-Tsu ChoChia-Yu Chu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.