First Case of Invasive Stachybotrys Sinusitis.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Margarita SemisMarkus Kalkum

Abstract

The toxigenic mold Stachybotrys has controversially been linked to idiopathic pulmonary hemorrhage and "sick building syndrome." However, there are no previous clinical records of invasive stachybotryosis. Sinus biopsy specimens from a 23-year-old male with refractory acute lymphocytic leukemia were obtained at 3 different time points during the patient's hospitalization (139 days) and examined by histopathology and immunohistochemistry (IHC). Antifungal susceptibility testing and fungal speciation using multilocus sequence typing were performed. Hemorrhage, fungal germination, and hyphal growth were observed in the first sinus biopsy tissues. Areas with fungal growth tested positive for Stachybotrys by IHC. Fungal isolates were genotyped and identified as Stachybotrys chlorohalonata. The patient was cured from Stachybotrys sinusitis following sinus surgery and antifungal treatment. While a subsequent second sinus biopsy and a bronchoscopy showed no signs of fungal infection, a later, third sinus biopsy tested positive for Aspergillus calidoustus, a rare human pathogen. Here, we report the first case of invasive S. chlorohalonata sinusitis that was surgically and medically cured but followed by invasive A. calidoustus sinusitis...Continue Reading

References

Dec 23, 1998·Occupational and Environmental Medicine·J D CooleyD C Straus
May 29, 1999·Environmental Health Perspectives·D G DearbornR A Etzel
Feb 10, 2004·The Journal of Allergy and Clinical Immunology·Mohammad Ashraf HossainMahmoud Afif Ghannoum
Sep 8, 2004·Advances in Applied Microbiology·De-Wei Li, Chin S Yang
Sep 8, 2004·Advances in Applied Microbiology·Eeva-Liisa Hintikka
Mar 10, 2005·Eukaryotic Cell·S Arunmozhi BalajeeKieren A Marr
Nov 17, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·James J PestkaJack R Harkema
May 21, 2008·Studies in Mycology·S A BalajeeR A Samson
Apr 14, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jamie H Rosenblum LichtensteinJoseph D Brain
Mar 23, 2011·Infection and Immunity·Diana Diaz-ArevaloMarkus Kalkum
Apr 24, 2019·Seminars in Diagnostic Pathology·Shawn R Lockhart, Jeannette Guarner

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