First catalytic asymmetric synthesis of beta-amino-beta-polyfluoroalkyl ketones via proline-catalysed direct asymmetric carbon-carbon bond formation reaction of polyfluoroalkylated aldimines

Chemical Communications : Chem Comm
Kazumasa FunabikiMasaki Matsui

Abstract

Proline-catalysed direct asymmetric carbon-carbon bond formation reaction of polyfluoroalkylated aldimines with acetone afforded the corresponding beta-(p-methoxyphenyl)amino-beta-polyfluoroalkyl ketones in high enantioselectivities (up to 98% ee).

References

Feb 28, 2002·Journal of the American Chemical Society·Armando CórdovaCarlos F Barbas
Feb 28, 2002·Journal of the American Chemical Society·Armando CórdovaCarlos F Barbas
Dec 6, 2003·The Journal of Organic Chemistry·Wolfgang NotzCarlos F Barbas

❮ Previous
Next ❯

Citations

Jun 21, 2005·Chemical Society Reviews·Jean-Pierre BéguéJulien Legros
Jul 24, 2015·The Journal of Organic Chemistry·Luca PariseStefania Fioravanti
Feb 8, 2007·Organic & Biomolecular Chemistry·A Louise Tillman, Darren J Dixon
Dec 13, 2007·Chemical Reviews·Santanu MukherjeeBenjamin List
Jul 27, 2021·ACS Catalysis·Chibueze I Onyeagusi, Steven J Malcolmson
Aug 22, 2012·Journal of the American Chemical Society·Yongwei Wu, Li Deng
May 20, 2006·The Journal of Organic Chemistry·Renata Marcia de FigueiredoMathias Christmann
Jul 1, 2005·Organic Letters·Alexander D DilmanVladimir A Tartakovsky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.