First Delayed Resection Findings After Irreversible Electroporation (IRE) of Human Localised Renal Cell Carcinoma (RCC) in the IRENE Pilot Phase 2a Trial

Cardiovascular and Interventional Radiology
Johann Jacob WendlerUwe-Bernd Liehr

Abstract

It is postulated that focal IRE affords complete ablation of soft-tissue tumours while protecting the healthy peritumoral tissue. Therefore, IRE may be an interesting option for minimally invasive, kidney-tissue-sparing, non-thermal ablation of renal tumours. With this current pilot study ("IRENE trial"), we present the first detailed histopathological data of IRE of human RCC followed by delayed tumour resection. The aim of this interim analysis of the first three patients was to investigate the ablation efficiency of percutaneous image-guided focal IRE in RCC, to assess whether a complete ablation of T1a RCC and tissue preservation with the NanoKnife system is possible and to decide whether the ablation parameters need to be altered. Following resection 4 weeks after percutaneous IRE, the success of ablation and detailed histopathological description were used to check the ablation parameters. The IRE led to a high degree of damage to the renal tumours (1 central, 2 peripheral; size range 15-17 mm). The postulated homogeneous, isomorphic damage was only partly confirmed. We found a zonal structuring of the ablation zone, negative margins and, enclosed within the ablation zone, very small tumour residues of unclear malignancy....Continue Reading

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Jul 12, 2016·Dr. Prof. M.P. Laguna Pes

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Citations

Jan 16, 2016·Current Urology Reports·Govindarajan Narayanan, Mehul H Doshi
Apr 28, 2016·Der Urologe. Ausg. A·J J WendlerM Schostak
Mar 12, 2016·Current Opinion in Urology·Nirmish Singla, Jeffrey Gahan
Jun 2, 2018·BioMed Research International·Guo TianTian'an Jiang
May 16, 2021·Journal of Biomechanical Engineering·Zheng FangBing Zhang

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