Abstract
It is postulated that focal IRE affords complete ablation of soft-tissue tumours while protecting the healthy peritumoral tissue. Therefore, IRE may be an interesting option for minimally invasive, kidney-tissue-sparing, non-thermal ablation of renal tumours. With this current pilot study ("IRENE trial"), we present the first detailed histopathological data of IRE of human RCC followed by delayed tumour resection. The aim of this interim analysis of the first three patients was to investigate the ablation efficiency of percutaneous image-guided focal IRE in RCC, to assess whether a complete ablation of T1a RCC and tissue preservation with the NanoKnife system is possible and to decide whether the ablation parameters need to be altered. Following resection 4 weeks after percutaneous IRE, the success of ablation and detailed histopathological description were used to check the ablation parameters. The IRE led to a high degree of damage to the renal tumours (1 central, 2 peripheral; size range 15-17 mm). The postulated homogeneous, isomorphic damage was only partly confirmed. We found a zonal structuring of the ablation zone, negative margins and, enclosed within the ablation zone, very small tumour residues of unclear malignancy....Continue Reading
References
Dec 11, 1999·Journal of Cancer Research and Clinical Oncology·Y NinomiyaT Nakajima
Mar 26, 2002·The Journal of Urology·Ricardo A RendonMichael A S Jewett
Apr 15, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Megan M GarrityThomas Witzig
Apr 18, 2007·BJU International·H Christoph KlinglerMartin Susani
Mar 31, 2009·The American Journal of Emergency Medicine·Peter B SmulowitzStephen K Epstein
Feb 10, 2010·Anesthesia and Analgesia·Christine BallHelen Kavnoudias
Aug 17, 2010·Cardiovascular and Interventional Radiology·Maciej PechUwe-Bernd Liehr
Nov 4, 2010·BJU International·Chad R TracyJeffrey A Cadeddu
Nov 30, 2010·Urology·Ajita DeodharStephen B Solomon
Mar 29, 2011·Journal of Vascular and Interventional Radiology : JVIR·Kenneth R ThomsonAndrew Haydon
Jun 3, 2011·Cardiovascular and Interventional Radiology·Johann Jakob WendlerUwe-Bernd Liehr
Aug 27, 2011·Cardiovascular and Interventional Radiology·Johann Jakob WendlerUwe-Bernd Liehr
Dec 6, 2011·European Urology·Martin MarszalekHendrik Van Poppel
Jun 21, 2012·Technology in Cancer Research & Treatment·L CalmelsL M Mir
Aug 16, 2012·Cardiovascular and Interventional Radiology·J J WendlerU-B Liehr
Nov 10, 2012·Der Urologe. Ausg. A·U-B LiehrM Schostak
Jan 8, 2013·Urology·Ephrem O OlwenyJeffrey A Cadeddu
Apr 24, 2013·Nature Reviews. Urology·Arturo CastroRaymond J Leveillee
Nov 26, 2013·Journal of Vascular and Interventional Radiology : JVIR·Christof M SommerBoris A Radeleff
Jul 24, 2014·Seminars in Interventional Radiology·Mikhail SilkRaymond H Thornton
Aug 12, 2014·World Journal of Surgical Oncology·Julie SteinestelAndres Jan Schrader
Sep 1, 2014·British Journal of Anaesthesia·K NielsenR A Bouwman
Dec 2, 2014·JOP : Journal of the Pancreas·Anna Maria IerardiGianpaolo Carrafiello
Dec 3, 2014·Journal of Vascular and Interventional Radiology : JVIR·Muneeb AhmedUNKNOWN Standard of Practice Committee of the Cardiovascular and Interventional Radiological Society of Europe
Dec 3, 2014·Journal of Vascular and Interventional Radiology : JVIR·Muneeb Ahmed, UNKNOWN Technology Assessment Committee of the Society of Interventional Radiology
Jan 23, 2015·Cardiovascular and Interventional Radiology·Jens RickeThierry De Baere
Jan 27, 2015·European Urology·Borje LjungbergAxel Bex
Mar 31, 2015·Journal of Vascular and Interventional Radiology : JVIR·Christoph NiessenPhilipp Wiggermann
May 13, 2015·Contemporary Clinical Trials·J J WendlerU B Liehr
Citations
Jan 16, 2016·Current Urology Reports·Govindarajan Narayanan, Mehul H Doshi
Jul 14, 2016·Radiology·Erik VelezMuneeb Ahmed
Sep 21, 2017·Cardiovascular and Interventional Radiology·J J WendlerU B Liehr
Apr 28, 2016·Der Urologe. Ausg. A·J J WendlerM Schostak
Feb 18, 2017·JMIR Research Protocols·Mara BuijsM Pilar Laguna
Mar 12, 2016·Current Opinion in Urology·Nirmish Singla, Jeffrey Gahan
Jun 2, 2018·BioMed Research International·Guo TianTian'an Jiang
May 16, 2021·Journal of Biomechanical Engineering·Zheng FangBing Zhang