First demonstration of gold nanorods-mediated photodynamic therapeutic destruction of tumors via near infra-red light activation

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Raviraj VankayalaKuo Chu Hwang

Abstract

Previously, a large volume of papers reports that gold nanorods (Au NRs) are able to effectively kill cancer cells upon high laser doses (usually 808 nm, 1-48 W/cm²) irradiation, leading to hyperthermia-induced destruction of cancer cells, i.e, photothermal therapy (PTT) effects. Combination of Au NRs-mediated PTT and organic photosensitizers-mediated photodynamic therapy (PDT) were also reported to achieve synergistic PTT and PDT effects on killing cancer cells. Herein, we demonstrate for the first time that Au NRs alone can sensitize formation of singlet oxygen (¹O₂) and exert dramatic PDT effects on complete destrcution of tumors in mice under very low LED/laser doses of single photon NIR (915 nm, <130 mW/cm²) light excitation. By changing the NIR light excitation wavelengths, Au NRs-mediated phototherapeutic effects can be switched from PDT to PTT or combination of both. Both PDT and PTT effects were confirmed by measurements of reactive oxygen species (ROS) and heat shock protein (HSP 70), singlet oxygen sensor green (SOSG) sensing, and sodium azide quenching in cellular experiments. In vivo mice experiments further show that the PDT effect via irradiation of Au NRs by 915 nm can destruct the B16F0 melanoma tumor in mice f...Continue Reading

References

Apr 3, 2001·Nature Biotechnology·R Weissleder
Feb 9, 2006·Journal of the American Chemical Society·Xiaohua HuangMostafa A El-Sayed
Aug 30, 2007·Critical Reviews in Biomedical Engineering·Riadh W Y HabashHafid T Alhafid
Sep 14, 2007·Chemical Communications : Chem Comm·Yasuro NiidomeJun-ichi Kikuchi
Jul 23, 2008·Journal of the American Chemical Society·Yu ChengClemens Burda
Jan 13, 2009·Bioconjugate Chemistry·Takahito KawanoTakuro Niidome
Mar 26, 2009·ACS Nano·Christopher J OrendorffJames A Voigt
Jun 6, 2009·Pigment Cell & Melanoma Research·Luís Sánchez-del-CampoJosé Neptuno Rodríguez-López
Aug 5, 2009·Chemical Communications : Chem Comm·Wen-Shuo KuoChen-Sheng Yeh
Mar 13, 2010·Small·Jingyi ChenYounan Xia
Feb 8, 2011·Journal of the American Chemical Society·Yu ChengClemens Burda
Mar 26, 2011·Macromolecular Bioscience·Dickson K KiruiCarl A Batt
Aug 13, 2011·Bioconjugate Chemistry·Sneha S Kelkar, Theresa M Reineke
Sep 21, 2011·Angewandte Chemie·Raviraj VankayalaKuo Chu Hwang
Dec 23, 2011·Chemical Society Reviews·Dong-Eun LeeIck Chan Kwon
Jun 28, 2012·Nano Today·Adam J GormleyHamidreza Ghandehari
Jul 11, 2012·Nano Letters·Mustafa YorulmazMichel Orrit

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Citations

Dec 15, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Jun SongParas N Prasad
Aug 30, 2014·Small·Li YanXianfeng Chen
Aug 22, 2015·Chemical Reviews·Xuan YangYounan Xia
Jun 20, 2015·Chemical Society Reviews·L ProdiN Zaccheroni
Jul 15, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Takashi D Y Kozai, Alberto L Vazquez
Dec 3, 2014·Cancer Letters·M C F SimõesA A C C Pais
May 31, 2016·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Samantha J ChadwickMartin Volk
Oct 11, 2016·Chemical Society Reviews·Wenpei FanXiaoyuan Chen
Mar 9, 2017·Nanoscale·Yanmei YangBengang Xing
Oct 25, 2016·Scientific Reports·Aby Cheruvathoor PouloseD Sakthi Kumar
May 16, 2015·Photodiagnosis and Photodynamic Therapy·Mona DoshiAndre J Gesquiere
Feb 21, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Arif GulzarPiaoping Yang
Jul 8, 2018·International Journal of Cancer. Journal International Du Cancer·Xiaoyang HouYanqun Liu
May 9, 2019·Advanced Healthcare Materials·Minhuan LanPengfei Wang
Oct 1, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Jie ZhaoJunbai Li
Jan 3, 2020·Photochemistry and Photobiology·Aaron J SorrinImran Rizvi
Jun 4, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Álvaro Cárcamo-MartínezRyan F Donnelly
Aug 19, 2020·Nature Materials·Guillaume BaffouRomain Quidant
Jun 23, 2015·Small·Timothée LabouretBruno Palpant
Nov 23, 2017·Nanoscale·Miguel M LinoLino Ferreira
Apr 9, 2020·International Journal of Molecular Sciences·Xue BaiLin Feng
Sep 15, 2020·ChemMedChem·Amarajothi DhakshinamoorthyHermenegildo Garcia
Jul 1, 2020·Advanced Drug Delivery Reviews·Young Hun ChungNicole F Steinmetz
Jan 12, 2021·Frontiers in Chemistry·Elisa CarrascoAlfonso Blázquez-Castro

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