First description of feline inflammatory mammary carcinoma: clinicopathological and immunohistochemical characteristics of three cases

Breast Cancer Research : BCR
Maria Dolores Pérez-AlenzaLaura Peña

Abstract

Inflammatory breast cancer is a special type of locally advanced mammary cancer that is associated with particularly aggressive behaviour and poor prognosis. The dog was considered the only natural model in which to study the disease because, until now, it was the only species known to present with inflammatory mammary carcinoma (IMC) spontaneously. In the present study we describe clinicopathological and immunohistochemical findings of three cats with IMC, in order to evaluate its possible value as an animal model. We prospectively studied three female cats with clinical symptoms of IMC, identified over a period of 3 years. Clinicopathological and immunohistochemical evaluations of Ki-67, and oestrogen, progesterone and androgen receptors were performed. All three animals presented with secondary IMC (postsurgical) characterized by a rapid onset of erythema, severe oedema, extreme local pain and firmness, absence of subjacent mammary nodules, and involvement of extremities. Rejection of the surgical suture was observed in two of the cats. Histologically, highly malignant papillary mammary carcinomas, dermal tumour embolization of superficial lymphatic vessels, and severe secondary inflammation were observed. The animals were p...Continue Reading

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Citations

Nov 18, 2011·Journal of the American Veterinary Medical Association·John E Bauer
Jan 18, 2012·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·A AkkocG Sonmez
Sep 13, 2011·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Jong-Hyuk KimJung-Hyang Sur
Apr 18, 2014·Veterinary Pathology·V ZappulliM Kiupel
Mar 3, 2010·Journal of Feline Medicine and Surgery·Fernanda GiménezAlfred M Legendre
Jan 19, 2016·Veterinary and Comparative Oncology·T P RaposoD J Argyle
Apr 25, 2006·Steroids·Juan C IlleraLaura Peña
Mar 13, 2012·Journal of Feline Medicine and Surgery·Francesca MillantaAlesandro Poli
Apr 23, 2013·Journal of Feline Medicine and Surgery·Joanna Morris
Feb 23, 2020·Journal of Feline Medicine and Surgery·Etienne FurthnerAlain Fontbonne
Jun 3, 2021·Veterinary Sciences·Maria SoaresFernando Ferreira

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Methods Mentioned

BETA
xenograft
biopsies
biopsy

Software Mentioned

Olympus [UNK] Image Analysis

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