First established pregnancy after controlled ovarian hyperstimulation with recombinant follicle stimulating hormone and the gonadotrophin-releasing hormone antagonist ganirelix (Org 37462)

Human Reproduction
J Itskovitz-EldorH Coelingh Bennink

Abstract

This case report describes the first established pregnancy after the use of gonadotrophin-releasing hormone (GnRH) antagonist, ganirelix (Org 37462; Organon), to prevent a premature luteinizing hormone surge during ovarian hyperstimulation with recombinant human follicle stimulating hormone (rhFSH). The pregnancy progressed normally and ended with the birth of a healthy boy and a girl after an elective Caesarean section at gestational age of 37 weeks. This case illustrates, for the first time, the use of a GnRH antagonist in combination with a pure FSH preparation for ovarian stimulation.

Citations

Apr 1, 2011·Human Reproduction Update·P HumaidanUNKNOWN Copenhagen GnRH Agonist Triggering Workshop Group
May 13, 2014·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Masakuni Suzuki
Jul 22, 2014·Reproductive Biomedicine Online·Peter Humaidan, Birgit Alsbjerg
Jul 5, 2013·International Journal of Endocrinology and Metabolism·Pilar AlamaJuan Giles
Feb 24, 2000·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A V Schally
Dec 27, 2011·Reproductive Biomedicine Online·Peter HumaidanHuman M Fatemi
Jun 16, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Maria Elisabetta CocciaGianfranco Scarselli
Jun 12, 2016·Reproductive Biology·Kemal OzgurKevin Coetzee
Apr 10, 2002·Human Fertility : Journal of the British Fertility Society·Henk J Out, Bernadette M J L Mannaerts
Feb 16, 2017·Journal of Assisted Reproduction and Genetics·Thi Ngoc Lan VuongP Humaidan
Apr 27, 2021·Current Opinion in Obstetrics & Gynecology·Peter Humaidan, Shahar Kol

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