First-ever ischemic stroke and increased risk of incident heart disease in older adults.

Neurology
Luciano A SposatoGustavo Saposnik

Abstract

Poststroke cardiac complications are common. It is unknown whether the reason is shared risk factors and preexisting heart disease or stroke-associated myocardial and coronary injury. We tested the hypothesis that first-ever ischemic stroke is associated with increased risk of incident cardiovascular complications in patients without known preexisting cardiac comorbid conditions. This population-based cohort study included residents in Ontario between 2002 and 2012 who were ≥66 years of age without known cardiovascular disease. We compared the incident risk of major adverse cardiovascular events (MACE), defined as myocardial infarction, unstable angina, congestive heart failure, coronary artery disease, coronary artery revascularization, or cardiovascular death, at 1 year in patients with first-ever ischemic stroke vs propensity-matched individuals without stroke (4:1 matching using 31 variables). To estimate cause-specific hazard ratios (HRs), we used Cox regression models adjusted for variables with weighted standardized differences >0.10 or known to influence the risk of MACE. We included 21,931 patients with first-ever ischemic stroke and 71,696 propensity-matched individuals, well balanced on all variables used for propens...Continue Reading

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Citations

Dec 30, 2020·Journal of Neurology·Jan F ScheitzMatthias Endres
Jan 10, 2020·Stroke; a Journal of Cerebral Circulation·Luciano A SposatoUNKNOWN PARADISE Study Group
Mar 10, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Amado Jimenez-RuizLuciano A Sposato
May 1, 2021·International Journal of Environmental Research and Public Health·Olive LennonCatherine Blake
Oct 26, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wei ChenZahid Hussain

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