First evidence of altered immune responses and resistance to air exposure in the clam Chamelea gallina exposed to benzo(a)pyrene

Archives of Environmental Contamination and Toxicology
V MatozzoM G Marin

Abstract

Effects of benzo(a)pyrene [B(a)P] (at a nominal concentration of 0.5 mg/L) on immune responses of the clam Chamelea gallina were investigated after 1, 7, and 12 days exposure. Total hemocyte count (THC), hemocyte volume, phagocytic activity, lysozyme-like activity in both hemocyte lysate (HL) and cell-free hemolymph (CFH) were measured. As unexpected alterations in hemocyte adhesion capability were observed in short-term hemocyte cultures for phagocytosis assays after a 1-day exposure, an adhesion test (not included in the original experimental setup) was performed after 7 and 12 days of exposure only. The survival-in-air test was carried out to evaluate general stress conditions in B(a)P-exposed clams. No alterations in THC was observed, whereas exposure for 7 and 12 days to B(a)P significantly decreased phagocytic activity and adhesion capability when compared with controls. Significant decreases in lysozyme activity were observed in CFH and HL, with respect to controls. B(a)P was also shown to alter the resistance to air exposure of clams. The LT(50) values fell from 9 days in control clams to 7 days in 1-day-exposed animals, and from 6 days in control clams to 5 days in 7-day-exposed bivalves. No significant variations in L...Continue Reading

References

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Sep 9, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Vanessa Moschino, Maria Gabriella Marin

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Citations

Jan 15, 2014·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Michele Boscolo PapoGiuseppe Radaelli
Aug 19, 2011·Ecotoxicology·Valerio MatozzoMaria Gabriella Marin
Jun 26, 2012·Marine Environmental Research·Valerio MatozzoMaria Gabriella Marin
Jul 14, 2010·Ecotoxicology and Environmental Safety·Marie L HannamMalcolm B Jones
Oct 14, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·M MonariG P Serrazanetti
Jul 23, 2014·Fish & Shellfish Immunology·Michele Boscolo PapoGiuseppe Radaelli
Oct 22, 2016·Food Chemistry·Silvia VincenzettiPaolo Polidori

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