First Evidence of DAAM1 Localization During the Post-Natal Development of Rat Testis and in Mammalian Sperm

Journal of Cellular Physiology
Paolo ParianteSergio Minucci

Abstract

Dishevelled-associated activator of morphogenesis 1 (DAAM1) is a formin-family protein involved in nucleation of unbranched actin filaments and in cytoskeletal organization through Wnt-Dishevelled PCP pathway, which participates in essential biological processes, such as cell polarity, movement, and adhesion during morphogenesis and organogenesis. While its role has been investigated during development and in somatic cells, its potential association with the germinal compartment and reproduction is still unexplored. In this work, we assessed the possible association of DAAM1 with the morphogenesis of rat testis. We studied its expression and profiled its localization versus actin and tubulin, during the first wave of spermatogenesis and in the adult gonad (from 7 to 60 dpp). We show that, in mitotic phases, DAAM1 shares its localization with actin in Sertoli cells, gonocytes, and spermatogonia. Later, during meiosis, both proteins are found in spermatocytes, while only actin is detectable at the forming blood-testis barrier. DAAM1, then, follows the development of the acrosome system throughout spermiogenesis, and it is finally retained inside the cytoplasmic droplet in mature gametes, as corroborated by additional immunolocali...Continue Reading

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Citations

Nov 1, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Massimo Venditti, Sergio Minucci
May 8, 2019·Zygote : the Biology of Gametes and Early Embryos·Massimo VendittiSergio Minucci
Apr 25, 2020·Molecular Reproduction and Development·Massimo VendittiImed Messaoudi
Aug 17, 2020·Zygote : the Biology of Gametes and Early Embryos·Massimo VendittiSergio Minucci
Sep 20, 2017·Seminars in Cell & Developmental Biology·Haiqi ChenC Yan Cheng
Aug 8, 2021·International Journal of Molecular Sciences·Massimo VendittiSergio Minucci

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