First Experience with Chemokine Receptor CXCR4-Targeted PET Imaging of Patients with Solid Cancers

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Tibor VagMarkus Schwaiger

Abstract

CXCR4 is a chemokine receptor that is overexpressed in various human cancers and is involved in tumor metastasis. The aim of this proof-of-concept study was to evaluate a novel CXCR4-targeted PET probe in patients with solid cancers with reported in vitro evidence of CXCR4 overexpression and to estimate its potential diagnostic value. Twenty-one patients with histologically proven pancreatic cancer, laryngeal cancer, non-small cell lung cancer, prostate cancer, melanoma, breast cancer, hepatocellular carcinoma, glioblastoma, sarcoma, or cancer of unknown primary underwent PET imaging using the novel CXCR4 nuclear probe (68)Ga-pentixafor. The SUVmax of the liver, spleen, and bone marrow was measured to determine physiologic tracer distribution. For evaluation of tracer accumulation in solid cancers, SUVmax and tumor-to-background (T/B) ratios were determined in a total of 43 malignant lesions, including 8 primary tumors, 3 locally recurrent tumors, and 32 metastases. When available, the SUVmax of malignant lesions was compared with the corresponding SUVmax measured in routine (18)F-FDG PET. Moderate tracer accumulation was detectable in the liver, bone marrow, and spleen, with a mean SUVmax of 3.1, 3.7, and 5.6, respectively. By...Continue Reading

References

Mar 23, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-P SpanoJ-C Soria
Dec 3, 2004·Cancer Research·Matthew C P SmithGary D Luker
May 14, 2005·Blood·Tsvee LapidotOrit Kollet
May 4, 2006·International Journal of Cancer. Journal International Du Cancer·Albert Zlotnik
Mar 3, 2009·Journal of Mammary Gland Biology and Neoplasia·Ciara S O'BrienRobert B Clarke
Apr 9, 2009·British Journal of Cancer·R MaréchalJ-L Van Laethem
Jun 27, 2009·Science·Jeffrey M Rosen, Craig T Jordan
May 21, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Beverly A Teicher, Simon P Fricker
Jul 3, 2010·Pathology International·Bungo FurusatoJohng S Rhim
Jun 3, 2011·Archives of Pathology & Laboratory Medicine·Shuting BaiGene P Siegal
Jul 23, 2011·ChemMedChem·Oliver DemmerHans-Jürgen Wester
Nov 3, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Eleni GourniHans-Jürgen Wester
Apr 27, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Alexander DrzezgaMarkus Schwaiger
Aug 29, 2012·The Journal of Thoracic and Cardiovascular Surgery·Duha FahhamOri Wald
Feb 6, 2013·Theranostics·Bikash DebnathNouri Neamati
Feb 6, 2013·Theranostics·Ido D Weiss, Orit Jacobson
Oct 9, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chin-Sheng HungYu-Jia Chang
Dec 25, 2013·Bioorganic & Medicinal Chemistry·Guillaume P C GeorgeEric O Aboagye
Jan 8, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying GaoXun Sun
Jul 23, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Tobias MaurerMatthias Eiber
Feb 24, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ken HerrmannMichael Lassmann
Mar 5, 2015·EMBO Molecular Medicine·Kathrin Philipp-AbbrederisUlrich Keller
Apr 1, 2015·Theranostics·Hans Jürgen WesterMarkus Schwaiger

❮ Previous
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Citations

Aug 19, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·D L BaileyT Beyer
Jan 23, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Ankit WattsD Behera
Nov 1, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Weijun WeiWeibo Cai
Apr 12, 2018·Investigative Radiology·Marius E MayerhoeferAlexander Haug
Mar 12, 2018·Journal of Neuro-oncology·Vladimir KepeErnest M Wright
Sep 25, 2019·Molecular Pharmacology·Ilze AdlereRob Leurs
Feb 6, 2020·Pharmaceuticals·Christine Rangger, Roland Haubner
Feb 29, 2020·Clinical Nuclear Medicine·Jie DingLi Huo
Mar 31, 2017·Current Cardiovascular Imaging Reports·Malte Kircher, Constantin Lapa
Jan 1, 2017·EJNMMI Radiopharmacy and Chemistry·Andreas PoschenriederHans-Jürgen Wester
Sep 3, 2019·Frontiers in Oncology·Rudolf A WernerConstantin Lapa
Jan 1, 2017·EJNMMI Radiopharmacy and Chemistry·Clément BaillyJacques Barbet
Apr 3, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Hanwen ZhangRonald Blasberg
Jun 10, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Eric O Aboagye, Françoise Kraeber-Bodéré
Feb 6, 2019·Nature Reviews. Clinical Oncology·Mirjam GerwingMoritz Wildgruber
Jan 31, 2017·International Journal of Molecular Sciences·Simone U DalmMarion De Jong
Aug 15, 2018·Annals of Nuclear Medicine·Malte KircherConstantin Lapa
Oct 23, 2020·Journal of Leukocyte Biology·Miguel MartinAlexandra Bobirca
Dec 7, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hsin-Yu FangMichael Quante
Jul 15, 2020·Nuclear Medicine and Biology·Hidefumi Mukai, Yasuyoshi Watanabe
Feb 14, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Philipp LindeCarsten Kobe
Mar 5, 2021·Journal of Medicinal Chemistry·Anna Maria TrottaSalvatore Di Maro
Dec 12, 2020·Nuclear Medicine Communications·Korrakode SirakriengkraiUsanee Techavijit
Aug 23, 2017·Seminars in Nuclear Medicine·Isaac M JacksonStephen Thompson
Apr 4, 2021·Diagnostics·Alexander WeichMalte Kircher
Jun 16, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Benjamin P BurkeStephen J Archibald
May 20, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Constantin LapaGötz Ulrich Grigoleit
Oct 28, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Malte KircherXiang Li
Sep 3, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Klaus KopkaJohn Babich
Sep 3, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Annemiek M E WalenkampHans-Jürgen Wester
Apr 26, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Peter HerhausUlrich Keller
May 26, 2021·Clinical Nuclear Medicine·Mehmet Onur DemirkolBurhan Ferhanoğlu

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