First experience with heterotopic thoracic pig-to-baboon cardiac xenotransplantation

Xenotransplantation
Andreas BauerPaolo Brenner

Abstract

Heterotopic thoracic heart transplantation may be an alternative to the established heterotopic abdominal or orthotopic cardiac xenotransplantation model as it combines the safety of heterotopic transplantation with the benefit of a working heart model. In a first series of two animals, we tested the surgical feasibility of this procedure with non-transgenic pig hearts transplanted into pre-sensitized baboons (killed after weaning from cardiopulmonary bypass). In a second group (n = 2), double-transgenic alpha(1,3)galactosyl-transferase knock out/hCD46 pig hearts were transplanted into naïve baboons after immunoadsorption. The immunosuppressive regimen consisted of anti-CD20-mAb, tacrolimus, sirolimus, MMF and steroids. The first baboon was successfully transplanted, but died of an air embolism, while in the second animal graft survival was 50 days with the recipient in good physical condition. One rejection reaction was successfully treated by immunoadsorption, ATG and the proteasome inhibitor bortezomib. Post-mortem histopathology showed no evidence for humoral or cellular rejection of the cardiac xenograft. This is the first description of a heterotopic thoracic pig-to-baboon heart transplantation. The procedure combines the...Continue Reading

References

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Citations

Oct 8, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Bruno ReichartJan-Michael Abicht
Mar 19, 2011·Current Opinion in Organ Transplantation·Burcin EkserDavid K C Cooper
Mar 19, 2011·Current Opinion in Organ Transplantation·Peter J CowanAnthony J F d'Apice
Feb 14, 2012·Current Opinion in Organ Transplantation·Guerard W Byrne, Christopher G A McGregor
Apr 12, 2012·Clinical Microbiology Reviews·Joachim Denner, Ralf R Tönjes
Aug 28, 2014·Current Opinion in Organ Transplantation·Alexander M Bernhardt, Hermann Reichenspurner
Jan 21, 2016·The Annals of Thoracic Surgery·Raghav MurthyDavid K C Cooper
Sep 1, 2015·International Journal of Surgery·Muhammad M MohiuddinChristopher G A McGregor
Dec 17, 2010·Xenotransplantation·Mårten K J Schneider, Jörg D Seebach
Oct 25, 2011·Lancet·Burcin EkserDavid K C Cooper
Oct 31, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Magdalena BoksaDaniel Lipiński
Mar 9, 2011·Journal of Molecular and Cellular Cardiology·Gerd HeuschRainer Schulz
Dec 17, 2014·International Journal of Surgery·Sebastian G MichelKumaran Shanmugarajah
Jun 24, 2020·Heart Failure Reviews·Songren ShuJiangping Song

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