Sep 1, 1976

First experiences with BS 100-141, a new antihypertensive substance

International Journal of Clinical Pharmacology and Biopharmacy
I Esch

Abstract

The administration of a new guanidine derivate, BS 100-141, to 20 patients resulted in a statistically highly significant reduction of blood pressure. A comparative clinical trial of BS 100-141 and alpha-methyl-DOPA showed BS 100-141 to be more efficient in lowering the arterial pressure than alpha-methyl-DOPA, especially when the drug was used in the second period of treatment. In the majority of the patients treated with BS 100-141 a slight increase in blood glucose concentration, not exceeding the upper limits of normal values, was found.

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Mentioned in this Paper

Diastolic Blood Pressure
Sembrina
Phenylacetic Acids
Hypertensive Disease
Antihypertensive Agents
Clinical Trials
Guanidines
Pulse Rate
Blood Glucose

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