First identification of blaOXA-51-like in non-baumannii Acinetobacter spp

Journal of Chemotherapy
Yi-Tzu LeeL-K Siu

Abstract

Bla(OXA-51-like), the intrinsic carbapenemase gene in Acinetobacter baumannii previously found only in this species, was detected in a clinical isolate of Acinetobacter genomic species 13tU. this study aimed to characterize this gene in the isolate. Genomic species identification was confirmed by amplified ribosomal DNA restriction analysis and sequence analysis of 16S-23S ribosomal DNA intergenic spacer, rpoB and recA. The bla(OXA-51-like) gene, with an upstream ISAba1 insertion, was plasmid-encoded and the surrounding sequences suggested that its origin was from A. baumannii. Transformation of Acinetobacter genomic species 13TU AtCC 17903 with recombinant plasmid bearing ISAba1-bla(OXA-51-like) from the isolate increased the minimum inhibitory concentrations (MICs) of meropenem and imipenem 256-fold. This is the first report of bla(OXA-51-like) in an organism other than A. baumannii. This plasmid-borne bla(OXA-51-like) gene with an upstream ISAba1 insertion confers a high level of carbapenem resistance to Acinetobacter genomic species 13TU.

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Citations

Jan 13, 2016·The Journal of Antimicrobial Chemotherapy·Steven J Nigro, Ruth M Hall
Nov 18, 2016·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Shirin BiglariBruno Silvester Lopes
May 11, 2017·Journal of Global Antimicrobial Resistance·Houda MorakchiJean-Marc Rolain
Sep 17, 2016·Protein Science : a Publication of the Protein Society·Cynthia M JuneDavid A Leonard
Jul 5, 2017·Antimicrobial Agents and Chemotherapy·Yi-Tzu LeeYa-Sung Yang
Jan 29, 2014·Antimicrobial Agents and Chemotherapy·Nuno T AntunesSergei B Vakulenko
Apr 4, 2014·Clinical Microbiology Reviews·Benjamin A Evans, Sebastian G B Amyes
Oct 20, 2011·Critical Reviews in Microbiology·Wei-Hua Zhao, Zhi-Qing Hu
Aug 25, 2020·FEMS Microbiology Ecology·Dipen PulamiStefanie P Glaeser
Mar 28, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Patrik MlynarcikMilan Kolar
Jan 1, 2014·Antibiotics·Nuno T Antunes, Jed F Fisher
Nov 1, 2020·The Journal of Antimicrobial Chemotherapy·Li-Hua LiUNKNOWN ACTION study group
Dec 19, 2020·The Journal of Antimicrobial Chemotherapy·Yuiko TakebayashiBenjamin A Evans
Jan 1, 2021·The Journal of Antimicrobial Chemotherapy·Eun-Jeong Yoon, Seok Hoon Jeong
Apr 21, 2021·Molecular and Cellular Probes·Soha Seyyedi AbhariFarzad Badmasti
Aug 31, 2021·Molecular Biology Reports·Susan IbrahimSarah Naji Aziz

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