First-in-Class Composite Angiotensin Receptor-Neprilysin Inhibitors (ARNI) in Practice.

Clinical Pharmacology and Therapeutics
M H Barghash, Akshay Desai

Abstract

Sacubitril/valsartan, a first-in-class angiotensin receptor-neprilysin inhibitor (ARNI) inhibits angiotensin II and neprilysin, enhancing circulating vasoactive peptides. It is recommended in heart failure with reduced ejection fraction (HFrEF) as a result of the PARADIGM-HF trial.1 This review discusses the rationale for neprilysin inhibition, data supporting efficacy, and practical tips for patient selection and utilization.

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Citations

Jul 19, 2017·Clinical Pharmacology and Therapeutics·P Honig, A Terzic

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