Abstract
Integrin-targeting radiopharmaceuticals have potential broad applications, spanning from cancer theranostics to cardiovascular diseases. We have previously reported preclinical dosimetry results of 68Ga-NODAGA-RGDyK in mice. This study presents the first human dosimetry of 68Ga-NODAGA-RGDyK in the five consecutive patients included in a clinical imaging protocol of carotid atherosclerotic plaques. Five male patients underwent whole-body time-of-flight (TOF) PET/CT scans 10, 60 and 120 min after tracer injection (200 MBq). Quantification of 68Ga activity concentration was first validated by a phantom study. To be used as input in OLINDA/EXM, time-activity curves were derived from manually drawn regions of interest over the following organs: brain, thyroid, lungs, heart, liver, spleen, stomach, kidneys, red marrow, pancreas, small intestine, colon, urinary bladder and whole body. A separate dosimetric analysis was performed for the choroid plexuses. Female dosimetry was extrapolated from male data. Effective doses (EDs) were estimated according to both ICRP60 and ICRP103 assuming 30-min and 1-h voiding cycles. The body regions receiving the highest dose were urinary bladder, kidneys and choroid plexuses. For a 30-min voiding cycl...Continue Reading
References
Jan 1, 1996·Annual Review of Cell and Developmental Biology·E Ruoslahti
Jan 22, 2004·Bioconjugate Chemistry·Roland HaubnerMarkus Schwaiger
Sep 24, 2004·Advanced Drug Delivery Reviews·Zoran B Redzic, Malcolm B Segal
Aug 16, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Ingrid DijkgraafOtto C Boerman
Feb 8, 2008·Cardiovascular Research·Takahiro HiguchiMarkus Schwaiger
May 24, 2008·Nature Reviews. Cancer·Christie J AvraamidesJudith A Varner
Jul 25, 2009·European Journal of Nuclear Medicine and Molecular Imaging· Johanna HaukkalaAnne Roivainen
Oct 8, 2009·Circulation. Cardiovascular Imaging·Iina LaitinenMarkus Schwaiger
Dec 17, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Li DongChun Yuan
Feb 4, 2010·Cancer·Ludovic FerrerManuel Bardiès
Apr 14, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Peter A KnetschRoland Haubner
Apr 20, 2011·Radiology·Erik S MittraSanjiv S Gambhir
Jul 19, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Rebecca A DumontMelpomeni Fani
Oct 13, 2011·Nuklearmedizin. Nuclear Medicine·F BucheggerJ O Prior
Oct 14, 2011·Medical Physics·V BettinardiM C Gilardi
Dec 14, 2011·Cancer Biotherapy & Radiopharmaceuticals·Joong Hyun KimDong Soo Lee
Feb 4, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hossam M SherifMarkus Schwaiger
Mar 27, 2012·Nuclear Medicine and Biology·Karolin PohleAmbros J Beer
Mar 28, 2012·Cancer Science·Arnaud BriatJean-Philippe Vuillez
Apr 14, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mohan DossJian Q Yu
May 15, 2013·EJNMMI Research·Iina LaitinenMarkus Schwaiger
May 16, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Luca MenichettiLeonardo Manzoni
Aug 7, 2013·Annals of Nuclear Medicine·Jin Chul PaengDong Soo Lee
Jan 15, 2014·JACC. Cardiovascular Imaging·Ambros J BeerMarkus Schwaiger
Jan 15, 2014·Nuclear Medicine and Biology·Jytte OxboelAndreas Kjaer
Mar 5, 2014·Radiology·Holger HetterichTobias Saam
Jun 24, 2014·Theranostics·Yi SunZhaohui Zhu
Dec 3, 2014·Nuclear Medicine and Biology·Sukhen C GhoshAli Azhdarinia
Feb 24, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Reza GolestaniRiemer H J A Slart
Jul 21, 2015·Bioconjugate Chemistry·Shuang Liu
Nov 21, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Victoria López-RodríguezMiguel A Ávila-Rodríguez
Nov 28, 2015·Neuroimaging Clinics of North America·Leo H Bonati, Paul J Nederkoorn
Jul 30, 2016·Current Opinion in Lipidology·Margreet R de Vries, Paul H A Quax
Dec 9, 2016·Heart·William S A JenkinsDavid E Newby
Citations
Aug 22, 2018·Oncology Letters·Meiqin YanXiangrong Cui
Dec 14, 2018·EJNMMI Research·Silvano GnesinJohn O Prior
Dec 11, 2019·Chemical Communications : Chem Comm·Sajid Mushtaq, Sang Hyun Park
May 10, 2020·EJNMMI Research·Steve DuranteJohn O Prior
Sep 13, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Thomas EbenhanMike Sathekge
Apr 10, 2020·EJNMMI Research·Silvano GnesinNiklaus Schaefer
Jan 30, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Francesco CiconeJohn O Prior
Sep 18, 2020·Nuclear Medicine Communications·Rakhee VatsaJaya Shukla
Jul 3, 2021·Molecular Biology Reports·Maria GrönmanAntti Saraste