First in-human radiation dosimetry of 68Ga-NODAGA-RGDyK

EJNMMI Research
Silvano GnesinJohn O Prior

Abstract

Integrin-targeting radiopharmaceuticals have potential broad applications, spanning from cancer theranostics to cardiovascular diseases. We have previously reported preclinical dosimetry results of 68Ga-NODAGA-RGDyK in mice. This study presents the first human dosimetry of 68Ga-NODAGA-RGDyK in the five consecutive patients included in a clinical imaging protocol of carotid atherosclerotic plaques. Five male patients underwent whole-body time-of-flight (TOF) PET/CT scans 10, 60 and 120 min after tracer injection (200 MBq). Quantification of 68Ga activity concentration was first validated by a phantom study. To be used as input in OLINDA/EXM, time-activity curves were derived from manually drawn regions of interest over the following organs: brain, thyroid, lungs, heart, liver, spleen, stomach, kidneys, red marrow, pancreas, small intestine, colon, urinary bladder and whole body. A separate dosimetric analysis was performed for the choroid plexuses. Female dosimetry was extrapolated from male data. Effective doses (EDs) were estimated according to both ICRP60 and ICRP103 assuming 30-min and 1-h voiding cycles. The body regions receiving the highest dose were urinary bladder, kidneys and choroid plexuses. For a 30-min voiding cycl...Continue Reading

Associated Clinical Trials

References

Jan 1, 1996·Annual Review of Cell and Developmental Biology·E Ruoslahti
Jan 22, 2004·Bioconjugate Chemistry·Roland HaubnerMarkus Schwaiger
Sep 24, 2004·Advanced Drug Delivery Reviews·Zoran B Redzic, Malcolm B Segal
Aug 16, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Ingrid DijkgraafOtto C Boerman
Feb 8, 2008·Cardiovascular Research·Takahiro HiguchiMarkus Schwaiger
May 24, 2008·Nature Reviews. Cancer·Christie J AvraamidesJudith A Varner
Jul 25, 2009·European Journal of Nuclear Medicine and Molecular Imaging· Johanna HaukkalaAnne Roivainen
Dec 17, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Li DongChun Yuan
Apr 14, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Peter A KnetschRoland Haubner
Jul 19, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Rebecca A DumontMelpomeni Fani
Oct 13, 2011·Nuklearmedizin. Nuclear Medicine·F BucheggerJ O Prior
Oct 14, 2011·Medical Physics·V BettinardiM C Gilardi
Feb 4, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hossam M SherifMarkus Schwaiger
Apr 14, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mohan DossJian Q Yu
May 16, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Luca MenichettiLeonardo Manzoni
Aug 7, 2013·Annals of Nuclear Medicine·Jin Chul PaengDong Soo Lee
Jan 15, 2014·JACC. Cardiovascular Imaging·Ambros J BeerMarkus Schwaiger
Dec 3, 2014·Nuclear Medicine and Biology·Sukhen C GhoshAli Azhdarinia
Feb 24, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Reza GolestaniRiemer H J A Slart
Nov 21, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Victoria López-RodríguezMiguel A Ávila-Rodríguez
Nov 28, 2015·Neuroimaging Clinics of North America·Leo H Bonati, Paul J Nederkoorn
Jul 30, 2016·Current Opinion in Lipidology·Margreet R de Vries, Paul H A Quax

❮ Previous
Next ❯

Citations

Sep 13, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Thomas EbenhanMike Sathekge
Apr 10, 2020·EJNMMI Research·Silvano GnesinNiklaus Schaefer
Jan 30, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Francesco CiconeJohn O Prior
Sep 18, 2020·Nuclear Medicine Communications·Rakhee VatsaJaya Shukla

❮ Previous
Next ❯

Software Mentioned

VPFXS
EXM ( Level INternal Dose Assessment / EXponential Modeling )
GE
OLINDA

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Victoria López-RodríguezMiguel A Ávila-Rodríguez
Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
F BretinE Salmon
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Pradeep K GargSudha Garg
Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Xiaoyun ZhouJohan R de Jong
© 2022 Meta ULC. All rights reserved