First Insights into Human Fingertip Regeneration by Echo-Doppler Imaging and Wound Microenvironment Assessment

International Journal of Molecular Sciences
Paris JafariSébastien Durand

Abstract

Fingertip response to trauma represents a fascinating example of tissue regeneration. Regeneration derives from proliferative mesenchymal cells (blastema) that subsequently differentiate into soft and skeletal tissues. Clinically, conservative treatment of the amputated fingertip under occlusive dressing can shift the response to tissue loss from a wound repair process towards regeneration. When analyzing by Immunoassay the wound exudate from occlusive dressings, the concentrations of brain-derived neurotrophic factor (BDNF) and leukemia inhibitory factor (LIF) were higher in fingertip exudates than in burn wounds (used as controls for wound repair versus regeneration). Vascular endothelial growth factor A (VEGF-A) and platelet-derived growth factor (PDGF) were highly expressed in both samples in comparable levels. In our study, pro-inflammatory cytokines were relatively higher expressed in regenerative fingertips than in the burn wound exudates while chemokines were present in lower levels. Functional, vascular and mechanical properties of the regenerated fingertips were analyzed three months after trauma and the data were compared to the corresponding fingertip on the collateral uninjured side. While sensory recovery and morp...Continue Reading

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Citations

Mar 29, 2019·Case Reports in Orthopedics·Debora SchivoSébastien Durand
Jan 31, 2021·Cells·Valentina DaponteAntonella Forlino
Mar 7, 2021·Annals of Plastic Surgery·Dallan DarganDavid Ralston

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Methods Mentioned

BETA
amputations

Software Mentioned

ImageJ
Luminex 100 IS
aixplorer

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