First line chemotherapy with planned sequential administration of gemcitabine followed by docetaxel in elderly advanced non-small-cell lung cancer patients: a multicenter phase II study.

British Journal of Cancer
C TibaldiAlfredo Falcone

Abstract

This multicenter phase II study evaluated, in chemonaive patients with stage IIIB-IV NSCLC, age >or=70 and with a performance status 0-2, the activity, efficacy and tolerability of planned sequential administration of gemcitabine 1200 mg m(-2) on days 1 and 8 every 3 weeks for three courses followed by three cycles of docetaxel 37.5 mg m(-2) on days 1 and 8 every 3 weeks, provided there was no evidence of disease progression. A total of 56 patients entered the study. According to intention-to-treat analysis, the objective response rate was 16.0% (95% CI 7.6-28.3%); 23 patients (41.0%) had stable disease and 24 patients (43%) had progressive disease. Five patients who had a stable disease after three courses of gemcitabine obtained a conversion to partial response by docetaxel. Median time to progression was 4.8 months (95% CI 3.6-6.0 months) and median duration of survival was 8.0 months (95% CI 5.6-10.5 months). The 1-year survival rate was 34%. No grade 4 haematological toxicity was observed and grade 3 neutropenia and thrombocytopenia were reported in 5.4 and 3.6% of the patients, respectively. Grade 3/4 mucositis and grade 3 diarrhoea, both occurred in 3.6% of the patients and grade 3 asthenia was observed in 9% of patients...Continue Reading

References

May 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F A ShepherdJ Berille
May 30, 2001·Lancet·V GeorgouliasUNKNOWN Greek Oncology Cooperative Group (GOCG) for Lung Cancer
Jul 3, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frank FossellaChandra P Belani
Dec 24, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David G PfisterUNKNOWN American Society of Clinical Oncology
Dec 18, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Marcus A NeubauerUNKNOWN Members of the US Oncology Study Group
Dec 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rogerio C LilenbaumMark R Green
Feb 25, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vassilis GeorgouliasDora Chatzidaki
Mar 3, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-L PujolC Clary
Mar 22, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·C TibaldiUNKNOWN POLTO group
Aug 9, 2005·Critical Reviews in Oncology/hematology·Martine ExtermannUNKNOWN Task Force on CGA of the International Society of Geriatric Oncology
Nov 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wolfgang SchuetteMonika Serke
Dec 24, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C CampsUNKNOWN Spanish Lung Cancer Group
Aug 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shinzoh KudohMasahiro Fukuoka
Sep 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ramaswamy GovindanJay Piccirillo
Nov 28, 2006·Revue des maladies respiratoires·C DujonP Petitpretz
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Paul J HeskethDavid R Gandara
May 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cesare GridelliSteven E Schild

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