First-line drugs for hypertension.

The Cochrane Database of Systematic Reviews
James M WrightRupam Gill

Abstract

This is the first update of a review published in 2009. Sustained moderate to severe elevations in resting blood pressure leads to a critically important clinical question: What class of drug to use first-line? This review attempted to answer that question. To quantify the mortality and morbidity effects from different first-line antihypertensive drug classes: thiazides (low-dose and high-dose), beta-blockers, calcium channel blockers, ACE inhibitors, angiotensin II receptor blockers (ARB), and alpha-blockers, compared to placebo or no treatment.Secondary objectives: when different antihypertensive drug classes are used as the first-line drug, to quantify the blood pressure lowering effect and the rate of withdrawal due to adverse drug effects, compared to placebo or no treatment. The Cochrane Hypertension Information Specialist searched the following databases for randomized controlled trials up to November 2017: the Cochrane Hypertension Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (from 1946), Embase (from 1974), the World Health Organization International Clinical Trials Registry Platform, and ClinicalTrials.gov. We contacted authors of relevant papers regarding further publish...Continue Reading

Associated Clinical Trials

References

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Jan 1, 1986·Drugs·P Leren, A Helgeland

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Citations

Jun 6, 2019·The Cochrane Database of Systematic Reviews·Vijaya M MusiniJames M Wright
Sep 6, 2019·Drug and Therapeutics Bulletin·James A Cave
Feb 7, 2020·The Cochrane Database of Systematic Reviews·Javier GarjónJuan Erviti
Jun 30, 2019·Drug and Therapeutics Bulletin·Teck K Khong, Elizabeth Adeyeye
Sep 25, 2020·Journal of General Internal Medicine·Michael E JohansenJeremey B Sussman
May 1, 2019·International Journal of Molecular Sciences·Uwe Gröber
Nov 6, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bart J KramersUNKNOWN DIPAK Consortium
Oct 2, 2020·Cancers·Fabian Bernhard Pallasch, Udo Schumacher
Jan 6, 2021·Pflügers Archiv : European journal of physiology·Satadru K LahiriXander H T Wehrens
Jan 13, 2021·BMJ Case Reports·Satoru MorikawaTaneaki Nakagawa
Sep 8, 2018·Deutsches Ärzteblatt International·Jens JordanHannes Reuter
May 13, 2021·BMC Medicine·Richu PhilipJonathan M Clarke
Feb 26, 2021·The Cochrane Database of Systematic Reviews·Ling-Ling LeeHui-Hsin Lin
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Chetta NgamjarusCharoonsak Somboonporn
Nov 28, 2021·The Cochrane Database of Systematic Reviews·Porjai PattanittumCharoonsak Somboonporn
Dec 17, 2021·Drug and Therapeutics Bulletin·Satoru MorikawaTaneaki Nakagawa

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