First-line gefitinib treatment for patients with advanced non-small cell lung cancer with poor performance status

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Young Joo LeeJin Soo Lee

Abstract

Best supportive care only is recommended for patients with advanced non-small cell lung cancer (NSCLC) with poor performance status (PS) of Eastern Cooperative Oncology Group 3 or 4. Recently, the possibility of using epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor therapy has been reported for poor PS patients harboring EGFR mutations. We retrospectively analyzed 74 patients with advanced NSCLC who were treated with first-line gefitinib during hospitalization for Eastern Cooperative Oncology Group PS 3 or 4. All patients were classified according to three clinical parameters: smoking history, gender, and histology type. The median age was 64 years (range, 35-86 years). The proportions of females, never smokers, and adenocarcinoma were 51.4%, 54.1%, and 78.4%, respectively. An overall response rate, median progression-free survival (PFS), and median overall survival (OS) was 27.0%, 32 days (95% confidence interval [CI], 22-48 days), and 61 days (95% CI, 7-115 days), respectively. Female gender, never smoking, and adenocarcinoma histology were strong predictors of tumor response. Never smoking and adenocarcinoma were independent predictors of better PFS but not of OS. Seven patients experienced treatment-relate...Continue Reading

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Citations

Sep 17, 2010·Journal of Experimental & Clinical Cancer Research : CR·Yong-Mei YinZhao-Xia Wang
Sep 4, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Bin-Chi LiaoJames Chih-Hsin Yang
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Mar 5, 2016·Cancer Investigation·Ya-Bing ZhengXi-Ping Zhang
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Jul 16, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shu-Yan HanPing-Ping Li
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