First line of biological drugs in rheumatoid arthritis: a medication persistence analysis

Expert Review of Clinical Pharmacology
Jéssica Barreto Ribeiro Dos SantosJuliana Alvares

Abstract

To evaluate the persistence of biological drugs used as the first line of biological treatment in patients diagnosed with rheumatoid arthritis. The predictors associated with persistence have also been verified. We evaluated a historical cohort composed of users of the Brazilian National Health System in the period between 2006 January and 2014 December. The endpoint was the medication persistence at 12 months. A population composed of 66,787 individuals started the first line of biological drug. Out of such individuals, 34,595 (51.80%) persisted in the treatment at 12 months. Abatacept was the drug that presented higher persistence, followed by golimumab, tocilizumab, etanercept, and adalimumab and, with lower persistence certolizumab and infliximab. Younger individuals, living in regions with higher social inequality by Gini coefficient, using certolizumab and infliximab in comparison with adalimumab presented a higher risk of non-persistence to treatment. Individuals from the Southeastern region were more persistent than Northeastern, Central-western, Northern and Southern regions. The medication persistence was different between biological drugs. The rigorous follow-up of patients, by a multidisciplinary team, is important ...Continue Reading

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Citations

Jun 14, 2019·Expert Review of Clinical Immunology·Michael Ruberson Ribeiro da SilvaFrancisco de Assis Acurcio
Jan 22, 2021·Expert Review of Pharmacoeconomics & Outcomes Research·Michael Ruberson Ribeiro da SilvaFrancisco De Assis Acurcio
Oct 23, 2020·Expert Review of Pharmacoeconomics & Outcomes Research·Jéssica Barreto Ribeiro Dos SantosJuliana Alvares-Teodoro
Nov 19, 2020·Expert Review of Clinical Immunology·Jéssica Barreto Ribeiro Dos SantosJuliana Alvares-Teodoro

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