First-line therapy for treatment-naive patients with advanced/metastatic renal cell carcinoma: a systematic review of published randomized controlled trials

Anti-cancer Drugs
Shweta TakyarHardev Pandha

Abstract

In the recent years, a number of targeted therapies have been approved for first-line treatment of patients with metastatic renal cell carcinoma. A systematic review was conducted to assess the clinical efficacy, safety and effect of all first-line treatments evaluated to date on health-related quality of life (HRQoL). A systematic search of Embase, Cochrane and MEDLINE databases was performed to identify randomized controlled trials (1980-2015) evaluating any targeted therapy/immunotherapy against placebo or any other targeted intervention/immunotherapy in treatment-naive patients with metastatic renal cell carcinoma. Conference proceedings from major cancer congresses (2007-2015) were handsearched. Sixteen randomized controlled trials were identified, mostly phase III. Overall, targeted therapies were associated with either improved [sunitinib, bevacizumab+interferon α (IFNα) and temsirolimus] or comparable (sorafenib) progression-free survival (PFS) versus IFNα monotherapy. Sunitinib demonstrated comparable PFS and overall survival to pazopanib, comparable PFS to sorafenib and shorter PFS compared with bevacizumab+IFNα (although no conclusions were made with regard to superiority/inferiority). Compared with sorafenib, tivoza...Continue Reading

References

Mar 22, 2007·Journal of the National Cancer Institute·Katherine S PanageasDeborah Schrag
Jun 1, 2007·The New England Journal of Medicine·Gary HudesUNKNOWN Global ARCC Trial
Nov 21, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S OudardR Motzer
Aug 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David CellaRobert J Motzer
Oct 22, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian I RiniEric J Small
Jan 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernard EscudierRonald M Bukowski
May 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernard EscudierRonald M Bukowski
Jun 3, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J MotzerRobert A Figlin
Jan 27, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cora N SternbergRobert E Hawkins
Jan 31, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Peter MuldersMartin E Gore
Jan 17, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Cora N SternbergIan D Davis
Apr 5, 2013·Anti-cancer Drugs·Sebastiano ButiFrancesco Massari
Aug 24, 2013·The New England Journal of Medicine·Robert J MotzerToni K Choueiri
Sep 11, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J MotzerThomas E Hutson
Apr 2, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernard EscudierDavid Cella
May 3, 2014·The New England Journal of Medicine·Robert J MotzerToni K Choueiri
Jan 27, 2015·European Urology·Borje LjungbergAxel Bex
Sep 17, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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Citations

Oct 21, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jianfeng WangJin Zhang
May 16, 2017·The Cochrane Database of Systematic Reviews·Susanne UnverzagtBarbara Seliger
Aug 21, 2019·Journal of Evidence-based Medicine·Frank PeinemannInes Moldenhauer
Aug 6, 2019·Frontiers in Oncology·Ning ShaoDingwei Ye
Aug 1, 2020·Nature Reviews. Nephrology·C Marcela Díaz-MonteroJames H Finke
Oct 30, 2020·Frontiers in Oncology·Wenjin ChenXingang Cui

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