First-line treatment in senior adults with metastatic castration-resistant prostate cancer: A prospective international registry

Urologic Oncology
Jean-Pierre DrozHaluk Ӧzen

Abstract

To compare the efficacy and tolerability of taxane and nontaxane therapy in senior adults with chemonaïve metastatic castration-resistant prostate cancer (mCRPC), and examine the effect of patient health status on outcomes. Between 2009 and 2011, 333 patients aged≥70 years with mCRPC were enrolled in a prospective international registry. Patients were categorized as having received taxane-based or nontaxane therapy, and classified as fit, vulnerable, frail, or terminal, according to investigator judgement or International Society of Geriatric Oncology guidelines. Efficacy measures included overall survival (OS) and progression-free survival. Grade 3/4 toxicities were recorded. Predictors of OS were identified using multivariate Cox regression. The proportions of fit/vulnerable/frail patients were 65%/14%/17% (International Society of Geriatric Oncology), and 39%/43%/17% (investigator). In single-factor analyses, taxane therapy improved OS (hazard ratio [95%CI] = 0.53 [0.30-0.93]; P = 0.027) and progression-free survival (hazard ratio [95% CI] = 0.55 [0.40-0.76]; P<0.001) vs. nontaxane therapy. Patients with frailty also benefited from taxane therapy (adapted regimen in 52%). In multivariate analysis, taxanes improved OS even wi...Continue Reading

Citations

Aug 24, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maria-Jose Molina-Garrido, Carmen Guillén-Ponce
Dec 22, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazumasa KomuraPhilip W Kantoff
Jan 6, 2019·European Journal of Clinical Pharmacology·Daniela FialováUNKNOWN EUROAGEISM H2020 project and WG1b group “Healthy clinical strategies for healthy aging” of the EU COST Action IS 1402
Jan 20, 2021·Future Oncology·Cedric PobelStéphane Oudard

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