First line treatment of aplastic anemia with thymoglobuline in Europe and Asia: Outcome of 955 patients treated 2001-2012

American Journal of Hematology
Andrea BacigalupoCarlos Vallejo

Abstract

The aim of this study was to assess the outcome of patients with aplastic anemia (AA), receiving rabbit anti-thymocyte globulin (Thymoglobulin, SANOFI) and cyclosporin, as first line treatment. Eligible were 955 patients with AA, treated first line with Thymoglobulin, between 2001 and 2008 (n = 492), or between 2009 and 2012 (n = 463). The median age of the patients was 21 years (range 1-84). Mortality within 90 days was 5.7% and 2.4%, respectively in the two time periods (P = .007).The actuarial 10-year survival for the entire population was 70%; transplant free survival was 64%. Predictors of survival in multivariate analysis, were severity of the disease, patients age and the interval between diagnosis and treatment. Survival was 87% vs 61% for responders at 6 months versus nonresponders (P < .0001). The 10-year survival of nonresponders at 6 months, undergoing a subsequent transplant (n = 110), was 64%, vs 60% for patient not transplantated (n = 266) (P = .1). The cumulative incidence of response was 37%, 52%, 65% respectively, at 90, 180, and 365 days. In multivariate analysis, negative predictors of response at 6 months, were older age, longer interval diagnosis treatment, and greater severity of the disease. In conclusio...Continue Reading

References

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Citations

Jun 18, 2019·British Journal of Haematology·Atsushi NaritaUNKNOWN Aplastic Anaemia Working Party of the Asia-Pacific Blood, Marrow Transplantation Group
Jan 11, 2019·International Journal of Hematology·Nana SasakiUNKNOWN Kyoto Clinical Hematology Study Group (KOTOSG) investigators
Nov 14, 2019·The Indian Journal of Medical Research·Salahuddin SiddiquiReinhold Munker
Sep 25, 2020·Journal of Pediatric Hematology/oncology·Fuxing LiXiaotian Xie
Mar 30, 2021·Deutsche medizinische Wochenschrift·Jens Panse
Jun 29, 2021·Medicina Clínica·Juan Carlos Vallejo Llamas
Jul 17, 2021·Annals of Hematology·Lalita NorasetthadaUNKNOWN Thai Aplastic Anemia Study Group

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