First molecular evidence of equine granulocytic anaplasmosis in Pakistan

Acta Tropica
Sehrish SaleemHui Zhang

Abstract

Anaplasma phagocytophilum (A. phagocytophilum) is an obligate intracellular bacterium that causes equine granulocytic anaplasmosis (EGA) disease in equines. This pathogen has zoonotic potential, which makes it very important to be detected and controlled as early as possible. This study was aimed to assess the molecular prevalence, associated risk factors of EGA along with its effects on various hematological parameters. This study revealed an overall 10.67% prevalence in equine. Horses showed highest prevalence followed by mules and donkeys presenting 11.86, 10.53 and 9.43% prevalence, respectively. The samples were confirmed for anaplasmosis through sequencing. The BLAST queries confirmed very high homology of our isolates with Chinese and Japanese isolates of A. phagocytophilum (Accession no's; KX505303, KY242456 and LC002836). The phylogenetic analysis found the study isolates clustered with each other and this cluster closely resembled Chinese isolate of A. bovis (FJ169957), A. phagocytophilum (HQ872464) and A. phagocytophilum (NR_044762) human isolate from northern Minnesota and Wisconsin. The key risk factors identified for occurrence of EGA in equine species on the basis of univariable analysis were sex of animal, housi...Continue Reading

Citations

Apr 1, 2020·The Journal of Parasitology·Awais GhaffarMuhammad Anas Naeem
Jan 5, 2020·Parasites & Vectors·Abdul GhafarAbdul Jabbar
Jan 12, 2019·The Korean Journal of Parasitology·Min-Goo SeoDongmi Kwak
Apr 13, 2021·The Journal of Parasitology·Hammad Nayyar GhauriAwais Ghaffar
Aug 14, 2021·Veterinary Microbiology·Hamid StajiSahar Ghaffari Khaligh
Sep 24, 2021·Tropical Animal Health and Production·João Bosco Vilela CamposHeitor Miraglia Herrera

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