PMID: 2502249May 20, 1989Paper

First myocardial infarctions in Asian and white men

BMJ : British Medical Journal
L O HughesE B Raftery

Abstract

To compare the presentation and natural course of first myocardial infarctions in immigrant Asians and the indigenous white population in Britain and the subsequent risk states of the two groups. Prospective ethnic comparison of consecutive patients with first myocardial infarctions. Secondary referrals to a coronary care unit of a district general hospital. 128 Men (77 white, 54 Asian) presenting consecutively with a first myocardial infarction diagnosed on the basis of clinical, biochemical, and electrocardiographic findings. Identification of mechanisms accounting for the increased rate of ischaemic heart disease in Asians. Infarct size was assessed by measuring the release of creatine phosphokinase (all patients), radionuclide ventriculography (50), and contrast ventriculography (103). Risk states after infarction were assessed from the degree of ventricular dysfunction as determined by exercise electrocardiography (82 patients) and from the extent of coronary atheroma as determined by coronary arteriography (103). Glucose state was measured in fasting venous blood samples. Overall the relative rate of infarction was 4.9 times higher in Asians (95% confidence interval 3.4 to 6.9) than in the white population. Moreover, the ...Continue Reading

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