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First occurrence of the OXA-198 carbapenemase in Enterobacterales

Antimicrobial Agents and Chemotherapy

Jan 15, 2020

Rémy A BonninThierry Naas

Abstract

A carbapenem-resistant Citrobacter spp. was recovered from routine screening of multidrug resistant bacteria. This isolate co-produced OXA-48 and OXA-198. OXA-48 was carried by the prototypical incL plasmid whereas OXA-198 was carried by a peculiar IncHI-type plasmid. This carbapenemase...read more

Mentioned in this Paper

Oxytocin, Asp(5)-
Carbapenemase
Plasmids
OXA-48 protein, Klebsiella
OXA1L
Screening Generic
Isolate - Microorganism
Paper Details
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First occurrence of the OXA-198 carbapenemase in Enterobacterales

Antimicrobial Agents and Chemotherapy

Jan 15, 2020

Rémy A BonninThierry Naas

PMID: 31932369

DOI: 10.1128/aac.01471-19

Abstract

A carbapenem-resistant Citrobacter spp. was recovered from routine screening of multidrug resistant bacteria. This isolate co-produced OXA-48 and OXA-198. OXA-48 was carried by the prototypical incL plasmid whereas OXA-198 was carried by a peculiar IncHI-type plasmid. This carbapenemase...read more

Mentioned in this Paper

Oxytocin, Asp(5)-
Carbapenemase
Plasmids
OXA-48 protein, Klebsiella
OXA1L
Screening Generic
Isolate - Microorganism

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CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Vitamin K Carboxylase & Antibiotics

Vitamin K-dependent carboxylases generate gamma-carboxyglutamic acids with malonate moieties by modifying glutamate residues in vitamin K-dependent proteins. This feed focuses on cellular mechanisms regulated by vitamin K-dependent carboxylases.

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The Lancet Infectious Diseases

Screening for carbapenem-resistant bacteria

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Paper Details
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