First-onset schizophrenia in the community: relationship of urbanization with onset, early manifestations and typology

Acta Psychiatrica Scandinavica
V K VarmaE S Susser

Abstract

As part of a World Health Organization collaborative study in 12 centres in developing and developed countries within defined urban and rural catchment areas with populations of 348,786 and 103,865, respectively, a total of 155 and 54 cases of first-onset schizophrenia, respectively, were identified over a 24-month period by a comprehensive and active recruitment of all cases. Approximately 50% of the subjects in both cohorts were in the age range of 15-24 years. There was a preponderance of males in the younger age group and of females in the older age group. The majority of cases had no family history and had shown good adjustment in childhood and adolescence. The onset was much more frequently acute and much less often insidious in our samples and (more so in the rural cohort), compared to the figure for all developed countries' sites. With regard to early manifestations of the disorder, there was a much higher incidence of loss of interest in appearance and cleanliness, being irritable and angry without reason, and loss of appetite, sleep or interest in sex in both of our samples, and of being excited or overactive for days or weeks in our rural cohort than in the developed countries' centres as a whole. On the other hand, ...Continue Reading

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Citations

Oct 12, 2001·The Psychiatric Clinics of North America·G Caracci, J E Mezzich
Sep 4, 2015·Indian Journal of Psychiatry·R Thara, Shantha Kamath
Dec 3, 2014·Asian Journal of Psychiatry·Susanta K PadhyBichitra N Patra
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