First Pandemic H1N1 Outbreak from a Pig Farm in Italy.

The Open Virology Journal
Ana MorenoPaolo Cordioli

Abstract

The first outbreak of the pandemic H1N1 virus in a swine breeder farm in Italy in November 2009 was reported. Clinical signs observed in sows included fever, depression, anorexia and agalactia, while in piglets diarrhoea and weight loss. The morbidity in sows was approximately 30% and the accumulated mortality rate was similar with those usually reported in piggeries (<10%). Virus was isolated from piglets (A/Sw/It/290271/09) and the sequencing of the whole genome was then performed. Comparison with all (H1N1)v sequences available in GenBank shows A/Sw/It/290271/09 three unique amino-acid (aa) changes in PB2 (S405T), PB1 (K386R) and PA (K256Q), not yet associated to any well characterized phenotype markers of Influenza viruses. All eight aa at positions representing the so-called species specific swine-human signatures, found in both swine and in the pandemic H1N1v, are also present. The M2 protein displays the C55F and the PA protein the S409N substitutions, both corresponding to enhanced transmission phenotype markers. Phylogenetic analysis showed that the virus was genetically related to the pandemic H1N1 virus. In addition, serological samples were collected from 40 sows, of which 20 resulted positive to the pandemic H1N1 v...Continue Reading

Citations

Dec 21, 2012·Animal Health Research Reviews·Qi ChenD L Hank Harris
Jan 10, 2012·Transboundary and Emerging Diseases·M TorremorellM Gramer
Oct 5, 2013·Genome Announcements·Chiara ChiapponiEmanuela Foni
Mar 19, 2013·Virology Journal·Nataya CharoenvisalRoongroje Thanawongnuwech
May 27, 2015·Influenza and Other Respiratory Viruses·Yeny O TinocoArmando E Gonzalez
Jun 6, 2012·Journal of Virological Methods·Chiara ChiapponiEmanuela Foni
Nov 28, 2013·Influenza and Other Respiratory Viruses·Emanuela FoniPaolo Cordioli
Jul 16, 2014·BioMed Research International·Arianna BoniAna Maria Moreno
Jul 25, 2014·The Journal of Veterinary Medical Science·Rikio KirisawaTokujiro Furuya
Jul 19, 2020·Viruses·Roland ZellRalf Dürrwald
Feb 23, 2021·The Journal of General Virology·Ahmed Magdy KhalilMakoto Ozawa

❮ Previous
Next ❯

Datasets Mentioned

BETA
CY053619
CY053621
CY053622
CY053620
CY053618
CY053617
CY053616
CY053623

Methods Mentioned

BETA
PCR

Software Mentioned

MEGA4
ClustalW

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.